TY - JOUR
T1 - A chromosome 15 quantitative trait locus controls levels of radiation-induced jejunal crypt cell apoptosis in mice
AU - Weil, Michael M.
AU - Xia, Chen
AU - Xia, Xueqing
AU - Gu, Xiangjun
AU - Amos, Christopher I.
AU - Mason, Kathryn A.
N1 - Funding Information:
The authors thank Mr. T. Lane Watkins and Mr. Jianfeng Chen for excellent technical assistance and Mr. Walter J. Pagel for editorial assistance. This work was supported in part by NIH Grants CA06294, ES09912, and HG02275. Some of the results in the paper were obtained by using the program packages Map Manager QT and MAPMAKER/QTL.
PY - 2001/2/15
Y1 - 2001/2/15
N2 - Jejunal crypt cells undergo apoptosis in response to ionizing radiation exposure. In mice the number of cells deleted by apoptosis is determined by several factors including the dose of radiation, the time of day the apoptosis level is quantified, and the strain of mouse irradiated. We previously found that the difference in radiation-induced apoptosis levels between C57BL/6J (B6) and C3Hf/Kam (C3H) mice is controlled by multiple genes, and this set of genes is distinct from that controlling thymocyte apoptosis levels in the same strain combination. Here, we report that a new quantitative trait locus on chromosome 15, Rapop5, partly accounts for the murine strain difference in susceptibility to radiation-induced jejunal crypt cell apoptosis. In addition, we show sexual dimorphism in the extent of radiation-induced jejunal crypt cell apoptosis, with female mice having higher levels.
AB - Jejunal crypt cells undergo apoptosis in response to ionizing radiation exposure. In mice the number of cells deleted by apoptosis is determined by several factors including the dose of radiation, the time of day the apoptosis level is quantified, and the strain of mouse irradiated. We previously found that the difference in radiation-induced apoptosis levels between C57BL/6J (B6) and C3Hf/Kam (C3H) mice is controlled by multiple genes, and this set of genes is distinct from that controlling thymocyte apoptosis levels in the same strain combination. Here, we report that a new quantitative trait locus on chromosome 15, Rapop5, partly accounts for the murine strain difference in susceptibility to radiation-induced jejunal crypt cell apoptosis. In addition, we show sexual dimorphism in the extent of radiation-induced jejunal crypt cell apoptosis, with female mice having higher levels.
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U2 - 10.1006/geno.2000.6465
DO - 10.1006/geno.2000.6465
M3 - Article
C2 - 11247668
AN - SCOPUS:0035864818
SN - 0888-7543
VL - 72
SP - 73
EP - 77
JO - Genomics
JF - Genomics
IS - 1
ER -