TY - JOUR
T1 - A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia
AU - Zhang, Haiying
AU - Ju, Guizhi
AU - Wei, Jun
AU - Hu, Ying
AU - Liu, Libo
AU - Xu, Qi
AU - Chen, Yang
AU - Sun, Zhiwei
AU - Liu, Shuzheng
AU - Yu, Yaqin
AU - Guo, Yingjun
AU - Shen, Yan
PY - 2006/7/10
Y1 - 2006/7/10
N2 - Recent studies suggest that both the KPNB3 gene and the KPNA3 gene in the long arm of chromosome 13 (13q) are associated with schizophrenia. Because these two genes belong to the same family of karyopherins, their combined effect on illness was investigated among 238 Chinese family trios consisting of fathers, mothers and affected offspring with schizophrenia. We detected three single nucleotide polymorphisms (SNPs), including rs626716 at the KPNB3 locus, and rs3782929 and rs3736830 at the KPNA3 locus. The transmission disequilibrium test (TDT) showed allelic association for rs626716 (X2 = 10.77, P = 0.001) and for rs3782929 (X2 = 4.89, P = 0.027) but not for rs3736830 (X2 = 0.29, P = 0.59). Although the conditional test did not show association either for the rs626716-rs3782929 combinations (X2 = 1.329, d.f. = 2, P = 0.514) or for the rs626716-rs3736830 combinations (X2 = 0.606, d.f. = 2, P = 0.739), the 1-d.f. test showed association for the rs626716(C)-rs3782929(G) combination (X2 = 10.79, P = 0.001) and for the rs626716(C)-rs3736830(G) combination (X2 = 8.64, P = 0.003). The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia.
AB - Recent studies suggest that both the KPNB3 gene and the KPNA3 gene in the long arm of chromosome 13 (13q) are associated with schizophrenia. Because these two genes belong to the same family of karyopherins, their combined effect on illness was investigated among 238 Chinese family trios consisting of fathers, mothers and affected offspring with schizophrenia. We detected three single nucleotide polymorphisms (SNPs), including rs626716 at the KPNB3 locus, and rs3782929 and rs3736830 at the KPNA3 locus. The transmission disequilibrium test (TDT) showed allelic association for rs626716 (X2 = 10.77, P = 0.001) and for rs3782929 (X2 = 4.89, P = 0.027) but not for rs3736830 (X2 = 0.29, P = 0.59). Although the conditional test did not show association either for the rs626716-rs3782929 combinations (X2 = 1.329, d.f. = 2, P = 0.514) or for the rs626716-rs3736830 combinations (X2 = 0.606, d.f. = 2, P = 0.739), the 1-d.f. test showed association for the rs626716(C)-rs3782929(G) combination (X2 = 10.79, P = 0.001) and for the rs626716(C)-rs3736830(G) combination (X2 = 8.64, P = 0.003). The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia.
KW - Chromosome 13q
KW - KPNA3
KW - KPNB3
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=33646796341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646796341&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2006.03.073
DO - 10.1016/j.neulet.2006.03.073
M3 - Article
C2 - 16644122
AN - SCOPUS:33646796341
SN - 0304-3940
VL - 402
SP - 173
EP - 175
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -