A comment on the absence of calcium regulation of human thioredoxin reductase

John E. Oblong; Garth Powis

doi:10.1016/0014-5793(93)81667-O

A comment on the absence of calcium regulation of human thioredoxin reductase

John E. Oblong, Garth Powis

Experimental Therapeutics

Research output: Contribution to journal › Comment/debate › peer-review

8 Scopus citations

Abstract

It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.

Original language	English (US)
Pages (from-to)	1-2
Number of pages	2
Journal	FEBS Letters
Volume	334
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(93)81667-O
State	Published - Nov 8 1993

Keywords

Calcium
Flavoenzyme
Human
Redox

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "A comment on the absence of calcium regulation of human thioredoxin reductase",

abstract = "It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.",

keywords = "Calcium, Flavoenzyme, Human, Redox",

author = "Oblong, {John E.} and Garth Powis",

note = "Funding Information: Acknowledgements. This work was supported by NIH Grant CA 42286 (G.P.) and by NIH Training Grant in Cancer Biology CA 09213 (J.E.O.).",

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AU - Powis, Garth

N1 - Funding Information: Acknowledgements. This work was supported by NIH Grant CA 42286 (G.P.) and by NIH Training Grant in Cancer Biology CA 09213 (J.E.O.).

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Y1 - 1993/11/8

N2 - It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.

AB - It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.

KW - Calcium

KW - Flavoenzyme

KW - Human

KW - Redox

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A comment on the absence of calcium regulation of human thioredoxin reductase

Abstract

Keywords

ASJC Scopus subject areas

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