A comparison between microsatellite analysis and cytology of urine for the detection of bladder cancer

Jianjun Zhang; Shan Zheng; Zhenbin Fan; Yanning Gao; Xuebing Di; Dong Wang; Zejun Xiao; Changling Li; Qian An; Shujun Cheng

doi:10.1016/S0304-3835(01)00609-7

A comparison between microsatellite analysis and cytology of urine for the detection of bladder cancer

Jianjun Zhang, Shan Zheng, Zhenbin Fan, Yanning Gao, Xuebing Di, Dong Wang, Zejun Xiao, Changling Li, Qian An, Shujun Cheng

Thoracic Head & Neck Medical Oncology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We have studied, in a blinded fashion, cytology and microsatellite analysis on urine sediments of 143 Chinese with or without bladder lesions. Microsatellite analysis succeeded in all 143 individuals, while cytology could not be performed on 42 subjects due to insufficient urine samples. Both microsatellite analysis and routine urine cytology succeeded in 81 bladder cancer patients. Seventy-three patients (90%) were identified by microsatellite analysis, while only 41 patients (51%) were identified by cytology. However, four patients were identified by routine cytology but not by microsatellite analysis. Our results proved that microsatellite analysis is more sensitive than routine cytology but the two methods are complementary to each other.

Original language	English (US)
Pages (from-to)	55-58
Number of pages	4
Journal	Cancer Letters
Volume	172
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(01)00609-7
State	Published - Oct 22 2001

Keywords

Bladder cancer
Diagnosis
Microsatellite alteration
Urine cytology

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/S0304-3835(01)00609-7

Cite this

@article{83c87c67f4a747b2a7e3a0e9ac65917f,

title = "A comparison between microsatellite analysis and cytology of urine for the detection of bladder cancer",

abstract = "We have studied, in a blinded fashion, cytology and microsatellite analysis on urine sediments of 143 Chinese with or without bladder lesions. Microsatellite analysis succeeded in all 143 individuals, while cytology could not be performed on 42 subjects due to insufficient urine samples. Both microsatellite analysis and routine urine cytology succeeded in 81 bladder cancer patients. Seventy-three patients (90%) were identified by microsatellite analysis, while only 41 patients (51%) were identified by cytology. However, four patients were identified by routine cytology but not by microsatellite analysis. Our results proved that microsatellite analysis is more sensitive than routine cytology but the two methods are complementary to each other.",

keywords = "Bladder cancer, Diagnosis, Microsatellite alteration, Urine cytology",

author = "Jianjun Zhang and Shan Zheng and Zhenbin Fan and Yanning Gao and Xuebing Di and Dong Wang and Zejun Xiao and Changling Li and Qian An and Shujun Cheng",

year = "2001",

month = oct,

day = "22",

doi = "10.1016/S0304-3835(01)00609-7",

language = "English (US)",

volume = "172",

pages = "55--58",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - A comparison between microsatellite analysis and cytology of urine for the detection of bladder cancer

AU - Zhang, Jianjun

AU - Zheng, Shan

AU - Fan, Zhenbin

AU - Gao, Yanning

AU - Di, Xuebing

AU - Wang, Dong

AU - Xiao, Zejun

AU - Li, Changling

AU - An, Qian

AU - Cheng, Shujun

PY - 2001/10/22

Y1 - 2001/10/22

N2 - We have studied, in a blinded fashion, cytology and microsatellite analysis on urine sediments of 143 Chinese with or without bladder lesions. Microsatellite analysis succeeded in all 143 individuals, while cytology could not be performed on 42 subjects due to insufficient urine samples. Both microsatellite analysis and routine urine cytology succeeded in 81 bladder cancer patients. Seventy-three patients (90%) were identified by microsatellite analysis, while only 41 patients (51%) were identified by cytology. However, four patients were identified by routine cytology but not by microsatellite analysis. Our results proved that microsatellite analysis is more sensitive than routine cytology but the two methods are complementary to each other.

AB - We have studied, in a blinded fashion, cytology and microsatellite analysis on urine sediments of 143 Chinese with or without bladder lesions. Microsatellite analysis succeeded in all 143 individuals, while cytology could not be performed on 42 subjects due to insufficient urine samples. Both microsatellite analysis and routine urine cytology succeeded in 81 bladder cancer patients. Seventy-three patients (90%) were identified by microsatellite analysis, while only 41 patients (51%) were identified by cytology. However, four patients were identified by routine cytology but not by microsatellite analysis. Our results proved that microsatellite analysis is more sensitive than routine cytology but the two methods are complementary to each other.

KW - Bladder cancer

KW - Diagnosis

KW - Microsatellite alteration

KW - Urine cytology

UR - http://www.scopus.com/inward/record.url?scp=0035935252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035935252&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(01)00609-7

DO - 10.1016/S0304-3835(01)00609-7

M3 - Article

C2 - 11595129

AN - SCOPUS:0035935252

SN - 0304-3835

VL - 172

SP - 55

EP - 58

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

A comparison between microsatellite analysis and cytology of urine for the detection of bladder cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this