A comparison of thermal enhancement of cis-diamminedichloro-platinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat

J. Wondergem; R. E. Bulger; Z. H. Siddik; J. W. Leygraaf; F. R. Strebel; M. Alonso; E. L. Travis; J. M.C. Bull

doi:10.1016/0360-3016(89)90961-9

A comparison of thermal enhancement of cis-diamminedichloro-platinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat

J. Wondergem, R. E. Bulger, Z. H. Siddik, J. W. Leygraaf, F. R. Strebel, M. Alonso, E. L. Travis, J. M.C. Bull

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Thermal enhancement of cis-diamminedichloroplatinum (II) (DDP) induced renal and intestinal toxicities by whole body hyperthermia (WBH) were compared using a F344 rat model. Thermal enhancement ratios (TER) for DDP-induced nephrotoxicity were calculated using renal functional assays and morphological techniques. TER values for gastrointestinal (G.I.) toxicity were calculated using "severity of diarrhea" and jejunal crypt cell survival as assays. TER's for renal damage varied between 3 and 3.4, whereas the TER measured for G.I.-toxicity was 1.8. Physiological changes caused by WBH or intrinsic differences in the sensitivities of normal tissues to DDP ± WBH may be responsible for the differences in thermal enhancement of DDP-induced renal and intestinal toxicities.

Original language	English (US)
Pages (from-to)	1551-1556
Number of pages	6
Journal	International journal of radiation oncology, biology, physics
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/0360-3016(89)90961-9
State	Published - Jun 1989

Keywords

Cis-platinum
Gastrointestinal toxicity
Renal toxicity
Whole body hyperthermia

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(89)90961-9

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Wondergem, J., Bulger, R. E., Siddik, Z. H., Leygraaf, J. W., Strebel, F. R., Alonso, M., Travis, E. L., & Bull, J. M. C. (1989). A comparison of thermal enhancement of cis-diamminedichloro-platinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat. International journal of radiation oncology, biology, physics, 16(6), 1551-1556. https://doi.org/10.1016/0360-3016(89)90961-9

A comparison of thermal enhancement of cis-diamminedichloro-platinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat. / Wondergem, J.; Bulger, R. E.; Siddik, Z. H. et al.
In: International journal of radiation oncology, biology, physics, Vol. 16, No. 6, 06.1989, p. 1551-1556.

Research output: Contribution to journal › Article › peer-review

Wondergem, J, Bulger, RE, Siddik, ZH, Leygraaf, JW, Strebel, FR, Alonso, M, Travis, EL & Bull, JMC 1989, 'A comparison of thermal enhancement of cis-diamminedichloro-platinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat', International journal of radiation oncology, biology, physics, vol. 16, no. 6, pp. 1551-1556. https://doi.org/10.1016/0360-3016(89)90961-9

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A comparison of thermal enhancement of cis-diamminedichloro-platinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat

Abstract

Keywords

ASJC Scopus subject areas

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