A composite T cell biomarker in pre-treatment blood samples correlates with detection of immune-related adverse events

Sangeeta Goswami; Bilal A. Siddiqui; Sumit K. Subudhi; Sreyashi Basu; Shalini S. Yadav; Adi Diab; Padmanee Sharma

doi:10.1016/j.ccell.2022.02.015

A composite T cell biomarker in pre-treatment blood samples correlates with detection of immune-related adverse events

Sangeeta Goswami, Bilal A. Siddiqui, Sumit K. Subudhi, Sreyashi Basu, Shalini S. Yadav, Adi Diab, Padmanee Sharma

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

Finding biomarkers for predicting anti-tumor responses and immune-related adverse events (irAEs) with immune checkpoint therapy remains a challenge. Lozano et al. have developed a composite biomarker score that includes the frequency of effector-memory CD4 T cells and TCR clonality of CD4 T cells in peripheral blood as a potentially predictive biomarker of irAEs.

Original language	English (US)
Pages (from-to)	249-251
Number of pages	3
Journal	Cancer cell
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/j.ccell.2022.02.015
State	Published - Mar 14 2022

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccell.2022.02.015

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title = "A composite T cell biomarker in pre-treatment blood samples correlates with detection of immune-related adverse events",

abstract = "Finding biomarkers for predicting anti-tumor responses and immune-related adverse events (irAEs) with immune checkpoint therapy remains a challenge. Lozano et al. have developed a composite biomarker score that includes the frequency of effector-memory CD4 T cells and TCR clonality of CD4 T cells in peripheral blood as a potentially predictive biomarker of irAEs.",

author = "Sangeeta Goswami and Siddiqui, {Bilal A.} and Subudhi, {Sumit K.} and Sreyashi Basu and Yadav, {Shalini S.} and Adi Diab and Padmanee Sharma",

note = "Funding Information: The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

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T1 - A composite T cell biomarker in pre-treatment blood samples correlates with detection of immune-related adverse events

AU - Goswami, Sangeeta

AU - Siddiqui, Bilal A.

AU - Subudhi, Sumit K.

AU - Basu, Sreyashi

AU - Yadav, Shalini S.

AU - Diab, Adi

AU - Sharma, Padmanee

PY - 2022/3/14

Y1 - 2022/3/14

N2 - Finding biomarkers for predicting anti-tumor responses and immune-related adverse events (irAEs) with immune checkpoint therapy remains a challenge. Lozano et al. have developed a composite biomarker score that includes the frequency of effector-memory CD4 T cells and TCR clonality of CD4 T cells in peripheral blood as a potentially predictive biomarker of irAEs.

AB - Finding biomarkers for predicting anti-tumor responses and immune-related adverse events (irAEs) with immune checkpoint therapy remains a challenge. Lozano et al. have developed a composite biomarker score that includes the frequency of effector-memory CD4 T cells and TCR clonality of CD4 T cells in peripheral blood as a potentially predictive biomarker of irAEs.

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U2 - 10.1016/j.ccell.2022.02.015

DO - 10.1016/j.ccell.2022.02.015

M3 - Comment/debate

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AN - SCOPUS:85125916148

SN - 1535-6108

VL - 40

SP - 249

EP - 251

JO - Cancer cell

JF - Cancer cell

IS - 3

ER -

A composite T cell biomarker in pre-treatment blood samples correlates with detection of immune-related adverse events

Abstract

ASJC Scopus subject areas

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