TY - JOUR
T1 - A comprehensive view of human chromosome 1
AU - White, Peter S.
AU - Sulman, Erik P.
AU - Porter, Christopher J.
AU - Matise, Tara C.
PY - 1999/10
Y1 - 1999/10
N2 - Comprehensive representations of human chromosomes combining diverse genomic data sets, localizing expressed sequences, and reflecting physical distance are essential for disease gene identification and sequencing efforts. We have developed a method (CompView) for integrating genomic information derived from available cytogenetic, genetic linkage, radiation hybrid, physical, and transcript-based mapping approaches. CompView generates chromosome representations with substantially higher resolution, coverage, and integration than current maps of the human genome. The CompView process was used to build a representation of human chromosome 1, yielding a map with > 13,000 unique elements, an effective resolution of 910 kb, and a marker density of 50 kb. CompView creates comprehensive and fully integrated depictions of a chromosome's clinical, biological, and structural information.
AB - Comprehensive representations of human chromosomes combining diverse genomic data sets, localizing expressed sequences, and reflecting physical distance are essential for disease gene identification and sequencing efforts. We have developed a method (CompView) for integrating genomic information derived from available cytogenetic, genetic linkage, radiation hybrid, physical, and transcript-based mapping approaches. CompView generates chromosome representations with substantially higher resolution, coverage, and integration than current maps of the human genome. The CompView process was used to build a representation of human chromosome 1, yielding a map with > 13,000 unique elements, an effective resolution of 910 kb, and a marker density of 50 kb. CompView creates comprehensive and fully integrated depictions of a chromosome's clinical, biological, and structural information.
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U2 - 10.1101/gr.9.10.978
DO - 10.1101/gr.9.10.978
M3 - Article
C2 - 10523526
AN - SCOPUS:0032697607
SN - 1088-9051
VL - 9
SP - 978
EP - 988
JO - Genome research
JF - Genome research
IS - 10
ER -