@article{ff2e425e48034cd98a07ff90b44c8bd1,
title = "A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis",
abstract = "XRCC4 was identified via a complementation cloning method that employed an ionizing radiation (IR)-sensitive hamster cell line. By gene-targeted mutation, we show that XRCC4 deficiency in primary murine cells causes growth defects, premature senescence, IR sensitivity, and inability to support V(D)J recombination. In mice, XRCC4 deficiency causes late embryonic lethality accompanied by defective lymphogenesis and defective neurogenesis manifested by extensive apoptotic death of newly generated postmitotic neuronal cells. We find similar neuronal developmental defects in embryos that lack DNA ligase IV, an XRCC4-associated protein. Our findings demonstrate that differentiating lymphocytes and neurons strictly require the XRCC4 and DNA ligase IV end-joining proteins and point to the general stage of neuronal development in which these proteins are necessary.",
author = "Yijie Gao and Yi Sun and Frank, {Karen M.} and Pieter Dikkes and Yuko Fujiwara and Seidl, {Katherine J.} and Sekiguchi, {Jo Ann M.} and Rathbun, {Gary A.} and Wojciech Swat and Jiyang Wang and Bronson, {Roderick T.} and Malynn, {Barbara A.} and Margaret Bryans and Chengming Zhu and Jayanta Chaudhuri and Laurie Davidson and Roger Ferrini and Thomas Stamato and Orkin, {Stuart H.} and Greenberg, {Michael E.} and Alt, {Frederick W.}",
note = "Funding Information: We thank Milton Datta, Landy Kangaloo, Cecilia Lundberg, Andr{\'e} Choulika, Jerold Chun, David Weaver, and Ronald DePinho for advice or assistance. The work was supported by the Howard Hughes Medical Institute, by National Institutes of Health grants A.I.20047 and A.I.35714 (F. A.), A.I.01428 (K. F.), C.A.61009 (B. M.), and GM50718 (G. R.), and by fellowships from the Damon Runyan Cancer Research Fund (Y. G. and J. C.), the Cancer Research Institute (C. Z.), the Life Sciences Research Foundation (K. F.), and the Leukemia Society of America (J. S.).",
year = "1998",
month = dec,
day = "23",
doi = "10.1016/S0092-8674(00)81714-6",
language = "English (US)",
volume = "95",
pages = "891--902",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "7",
}