TY - JOUR
T1 - A cumulative experience examining the effect of natural and synthetic antimicrobial peptides vs. Chlamydia trachomatis
AU - Yasin, B.
AU - Pang, M.
AU - Lehrer, R. I.
AU - Wagar, E. A.
PY - 2004/8
Y1 - 2004/8
N2 - We tested the activity of 48 structurally diverse antimicrobial peptides against Chlamydia trachomatis, serovar L2. The peptides' activity against C. trachomatis, serovar L2 was measured in 48-h McCoy cell shell vial assays. Peptides of 16-20 amino acids were more active than larger peptides, such as defensins. β-Sheet protegrins, as well as α-helical peptides such as novispirin (G-10) were equally active. Enantiomers were as active as native structures. Moderate-sized circular mini-defensins were less effective against C. trachomatis. Moderate-sized cationic peptides may be useful in microbicide preparations designed to prevent chlamydial infection.
AB - We tested the activity of 48 structurally diverse antimicrobial peptides against Chlamydia trachomatis, serovar L2. The peptides' activity against C. trachomatis, serovar L2 was measured in 48-h McCoy cell shell vial assays. Peptides of 16-20 amino acids were more active than larger peptides, such as defensins. β-Sheet protegrins, as well as α-helical peptides such as novispirin (G-10) were equally active. Enantiomers were as active as native structures. Moderate-sized circular mini-defensins were less effective against C. trachomatis. Moderate-sized cationic peptides may be useful in microbicide preparations designed to prevent chlamydial infection.
KW - Antimicrobial peptides
KW - Chlamydia trachomatis
KW - Circular mini-defensins
KW - Defensins
KW - Host-defense peptides
KW - Protegrins
UR - http://www.scopus.com/inward/record.url?scp=3843140679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3843140679&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3011.2004.00172.x
DO - 10.1111/j.1399-3011.2004.00172.x
M3 - Article
C2 - 15251032
AN - SCOPUS:3843140679
SN - 1397-002X
VL - 64
SP - 65
EP - 71
JO - Journal of Peptide Research
JF - Journal of Peptide Research
IS - 2
ER -