A dose-surviving fraction curve for mouse colonic mucosa

Susan L. Tucker; H. Rodney Withers; Kathryn A. Mason; Howard D. Thames

doi:10.1016/0277-5379(83)90143-8

A dose-surviving fraction curve for mouse colonic mucosa

Susan L. Tucker, H. Rodney Withers, Kathryn A. Mason, Howard D. Thames

Research output: Contribution to journal › Article › peer-review

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Abstract

A dose-surviving fraction curve representing the response of the mouse colonic mucosa to single doses of ¹³⁷Cs gamma radiation was obtained from the results of a multifraction in vivo colony assay. Construction of the curve required an estimate of the average number of clonogens initially present per colonic crypt. The estimated clonogen count (88) was determined by a statistical method based on the use of doses per fraction common to different fractionation protocols. Parameters for the LQ and TC models of cell survival were obtained by weighted least-squares fits to the data. A comparison of the survival characteristics of cells from the mouse colonic and jejunal crypts suggested that the epithelium of the colon is less radiosensitive than that of the jejunum.

Original language	English (US)
Pages (from-to)	433-437
Number of pages	5
Journal	European Journal of Cancer and Clinical Oncology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0277-5379(83)90143-8
State	Published - Mar 1983

ASJC Scopus subject areas

Oncology

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10.1016/0277-5379(83)90143-8

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title = "A dose-surviving fraction curve for mouse colonic mucosa",

abstract = "A dose-surviving fraction curve representing the response of the mouse colonic mucosa to single doses of 137Cs gamma radiation was obtained from the results of a multifraction in vivo colony assay. Construction of the curve required an estimate of the average number of clonogens initially present per colonic crypt. The estimated clonogen count (88) was determined by a statistical method based on the use of doses per fraction common to different fractionation protocols. Parameters for the LQ and TC models of cell survival were obtained by weighted least-squares fits to the data. A comparison of the survival characteristics of cells from the mouse colonic and jejunal crypts suggested that the epithelium of the colon is less radiosensitive than that of the jejunum.",

author = "Tucker, {Susan L.} and Withers, {H. Rodney} and Mason, {Kathryn A.} and Thames, {Howard D.}",

note = "Funding Information: Accepted 8 September 1982. *Supported in part by Research Grants CA-29026, CA-l 1430, and CA-11 138 from the National Institutes of Health, Bethesda, Maryland.",

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T1 - A dose-surviving fraction curve for mouse colonic mucosa

AU - Tucker, Susan L.

AU - Withers, H. Rodney

AU - Mason, Kathryn A.

AU - Thames, Howard D.

N1 - Funding Information: Accepted 8 September 1982. *Supported in part by Research Grants CA-29026, CA-l 1430, and CA-11 138 from the National Institutes of Health, Bethesda, Maryland.

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N2 - A dose-surviving fraction curve representing the response of the mouse colonic mucosa to single doses of 137Cs gamma radiation was obtained from the results of a multifraction in vivo colony assay. Construction of the curve required an estimate of the average number of clonogens initially present per colonic crypt. The estimated clonogen count (88) was determined by a statistical method based on the use of doses per fraction common to different fractionation protocols. Parameters for the LQ and TC models of cell survival were obtained by weighted least-squares fits to the data. A comparison of the survival characteristics of cells from the mouse colonic and jejunal crypts suggested that the epithelium of the colon is less radiosensitive than that of the jejunum.

AB - A dose-surviving fraction curve representing the response of the mouse colonic mucosa to single doses of 137Cs gamma radiation was obtained from the results of a multifraction in vivo colony assay. Construction of the curve required an estimate of the average number of clonogens initially present per colonic crypt. The estimated clonogen count (88) was determined by a statistical method based on the use of doses per fraction common to different fractionation protocols. Parameters for the LQ and TC models of cell survival were obtained by weighted least-squares fits to the data. A comparison of the survival characteristics of cells from the mouse colonic and jejunal crypts suggested that the epithelium of the colon is less radiosensitive than that of the jejunum.

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A dose-surviving fraction curve for mouse colonic mucosa

Abstract

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