A fast and accurate timing alignment method with TDC linearity calibration for a high-resolution TOF-PET

Hongdi Li; Chao Wang; Shaohui An; Xingyu Lv; Yun Dong; Shitao Liu; Hossain Baghaei; Yuxuan Zhang; Rocio Ramirez; Wai Hoi Wong

doi:10.1109/NSSMIC.2013.6829394

A fast and accurate timing alignment method with TDC linearity calibration for a high-resolution TOF-PET

Hongdi Li, Chao Wang, Shaohui An, Xingyu Lv, Yun Dong, Shitao Liu, Hossain Baghaei, Yuxuan Zhang, Rocio Ramirez, Wai Hoi Wong

Cancer Systems Imaging

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

An accurate PET system timing alignment minimizes the coincidence time-window for reducing random events and improves image quality; it also is critical for time-of-flight (TOF) image reconstruction. In this work, we proposed to use a thin cylindrical ring (shell) phantom filled with radioactive source and located axially and centrally in a camera for the alignment of a high time-resolution TOF PET system. The timing alignment method involves measuring the time differences between the selected coincidence detector pairs, calibrating the differential and integral non-linearity of TDC with the same raw data, and deriving the intrinsic timing biases for each detector using an iterative algorithm. The raw time bias for each crystal will be downloaded to the front-end EPROM and the residual fine bias can be applied to the TOF list-mode reconstruction.

Original language	English (US)
Title of host publication	2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Print)	9781479905348
DOIs	https://doi.org/10.1109/NSSMIC.2013.6829394
State	Published - 2013
Event	2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of Duration: Oct 27 2013 → Nov 2 2013

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
ISSN (Print)	1095-7863

Other

Other	2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
Country/Territory	Korea, Republic of
City	Seoul
Period	10/27/13 → 11/2/13

Keywords

Positron emission tomography (PET)
TDC non-linearity
TOF
Timing alignment

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

Access to Document

10.1109/NSSMIC.2013.6829394

Cite this

Li, H., Wang, C., An, S., Lv, X., Dong, Y., Liu, S., Baghaei, H., Zhang, Y., Ramirez, R., & Wong, W. H. (2013). A fast and accurate timing alignment method with TDC linearity calibration for a high-resolution TOF-PET. In 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 Article 6829394 (IEEE Nuclear Science Symposium Conference Record). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2013.6829394

A fast and accurate timing alignment method with TDC linearity calibration for a high-resolution TOF-PET. / Li, Hongdi; Wang, Chao; An, Shaohui et al.
2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013. Institute of Electrical and Electronics Engineers Inc., 2013. 6829394 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Li, H, Wang, C, An, S, Lv, X, Dong, Y, Liu, S, Baghaei, H, Zhang, Y, Ramirez, R & Wong, WH 2013, A fast and accurate timing alignment method with TDC linearity calibration for a high-resolution TOF-PET. in 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013., 6829394, IEEE Nuclear Science Symposium Conference Record, Institute of Electrical and Electronics Engineers Inc., 2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013, Seoul, Korea, Republic of, 10/27/13. https://doi.org/10.1109/NSSMIC.2013.6829394

Li H, Wang C, An S, Lv X, Dong Y, Liu S et al. A fast and accurate timing alignment method with TDC linearity calibration for a high-resolution TOF-PET. In 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013. Institute of Electrical and Electronics Engineers Inc. 2013. 6829394. (IEEE Nuclear Science Symposium Conference Record). doi: 10.1109/NSSMIC.2013.6829394

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title = "A fast and accurate timing alignment method with TDC linearity calibration for a high-resolution TOF-PET",

abstract = "An accurate PET system timing alignment minimizes the coincidence time-window for reducing random events and improves image quality; it also is critical for time-of-flight (TOF) image reconstruction. In this work, we proposed to use a thin cylindrical ring (shell) phantom filled with radioactive source and located axially and centrally in a camera for the alignment of a high time-resolution TOF PET system. The timing alignment method involves measuring the time differences between the selected coincidence detector pairs, calibrating the differential and integral non-linearity of TDC with the same raw data, and deriving the intrinsic timing biases for each detector using an iterative algorithm. The raw time bias for each crystal will be downloaded to the front-end EPROM and the residual fine bias can be applied to the TOF list-mode reconstruction.",

keywords = "Positron emission tomography (PET), TDC non-linearity, TOF, Timing alignment",

author = "Hongdi Li and Chao Wang and Shaohui An and Xingyu Lv and Yun Dong and Shitao Liu and Hossain Baghaei and Yuxuan Zhang and Rocio Ramirez and Wong, {Wai Hoi}",

note = "Copyright: Copyright 2014 Elsevier B.V., All rights reserved.; 2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 ; Conference date: 27-10-2013 Through 02-11-2013",

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doi = "10.1109/NSSMIC.2013.6829394",

language = "English (US)",

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AU - Li, Hongdi

AU - Wang, Chao

AU - An, Shaohui

AU - Lv, Xingyu

AU - Dong, Yun

AU - Liu, Shitao

AU - Baghaei, Hossain

AU - Zhang, Yuxuan

AU - Ramirez, Rocio

AU - Wong, Wai Hoi

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N2 - An accurate PET system timing alignment minimizes the coincidence time-window for reducing random events and improves image quality; it also is critical for time-of-flight (TOF) image reconstruction. In this work, we proposed to use a thin cylindrical ring (shell) phantom filled with radioactive source and located axially and centrally in a camera for the alignment of a high time-resolution TOF PET system. The timing alignment method involves measuring the time differences between the selected coincidence detector pairs, calibrating the differential and integral non-linearity of TDC with the same raw data, and deriving the intrinsic timing biases for each detector using an iterative algorithm. The raw time bias for each crystal will be downloaded to the front-end EPROM and the residual fine bias can be applied to the TOF list-mode reconstruction.

AB - An accurate PET system timing alignment minimizes the coincidence time-window for reducing random events and improves image quality; it also is critical for time-of-flight (TOF) image reconstruction. In this work, we proposed to use a thin cylindrical ring (shell) phantom filled with radioactive source and located axially and centrally in a camera for the alignment of a high time-resolution TOF PET system. The timing alignment method involves measuring the time differences between the selected coincidence detector pairs, calibrating the differential and integral non-linearity of TDC with the same raw data, and deriving the intrinsic timing biases for each detector using an iterative algorithm. The raw time bias for each crystal will be downloaded to the front-end EPROM and the residual fine bias can be applied to the TOF list-mode reconstruction.

KW - Positron emission tomography (PET)

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A fast and accurate timing alignment method with TDC linearity calibration for a high-resolution TOF-PET

Abstract

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Keywords

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