Abstract
To account for the correlation between failure and censoring, we propose a new frailty model for clustered data. In this model, the risk to be censored is affected by the risk of failure. This model allows flexibility in the direction and degree of dependence between failure and censoring. It includes the traditional frailty model as a special case. It allows censoring by some causes to be analyzed as informative while treating censoring by other causes as noninformative. It can also analyze data for competing risks. To fit the model, the EM algorithm is used with Markov chain Monte Carlo simulations in the E-steps. Simulation studies and analysis of data for kidney disease patients are provided. Consequences of incorrectly assuming noninformative censoring are investigated.
Original language | English (US) |
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Pages (from-to) | 510-520 |
Number of pages | 11 |
Journal | Biometrics |
Volume | 58 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2002 |
Externally published | Yes |
Keywords
- Clustered data
- Competing risks
- Dependent censoring
- EM algorithm
- Survival analysis
ASJC Scopus subject areas
- Statistics and Probability
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology
- General Agricultural and Biological Sciences
- Applied Mathematics