A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2

Samuel C. Mok; Tomas Bonome; Vinod Vathipadiekal; Aaron Bell; Michael E. Johnson; kwong kwok Wong; Dong Choon Park; Ke Hao; Daniel K.P. Yip; Howard Donninger; Laurent Ozbun; Goli Samimi; John Brady; Mike Randonovich; Cindy A. Pise-Masison; J. Carl Barrett; Wing H. Wong; William R. Welch; Ross S. Berkowitz; Michael J. Birrer

doi:10.1016/j.ccr.2009.10.018

A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2

Samuel C. Mok, Tomas Bonome, Vinod Vathipadiekal, Aaron Bell, Michael E. Johnson, kwong kwok Wong, Dong Choon Park, Ke Hao, Daniel K.P. Yip, Howard Donninger, Laurent Ozbun, Goli Samimi, John Brady, Mike Randonovich, Cindy A. Pise-Masison, J. Carl Barrett, Wing H. Wong, William R. Welch, Ross S. Berkowitz, Michael J. Birrer

Gynecological Oncology & Reproductive Medicine

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the α_Vβ₃ integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.

Original language	English (US)
Pages (from-to)	521-532
Number of pages	12
Journal	Cancer cell
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.ccr.2009.10.018
State	Published - Dec 8 2009

Keywords

CELLCYCLE

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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Mok, S. C., Bonome, T., Vathipadiekal, V., Bell, A., Johnson, M. E., Wong, K. K., Park, D. C., Hao, K., Yip, D. K. P., Donninger, H., Ozbun, L., Samimi, G., Brady, J., Randonovich, M., Pise-Masison, C. A., Barrett, J. C., Wong, W. H., Welch, W. R., Berkowitz, R. S., & Birrer, M. J. (2009). A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2. Cancer cell, 16(6), 521-532. https://doi.org/10.1016/j.ccr.2009.10.018

Mok, SC, Bonome, T, Vathipadiekal, V, Bell, A, Johnson, ME, Wong, KK, Park, DC, Hao, K, Yip, DKP, Donninger, H, Ozbun, L, Samimi, G, Brady, J, Randonovich, M, Pise-Masison, CA, Barrett, JC, Wong, WH, Welch, WR, Berkowitz, RS & Birrer, MJ 2009, 'A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2', Cancer cell, vol. 16, no. 6, pp. 521-532. https://doi.org/10.1016/j.ccr.2009.10.018

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title = "A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2",

abstract = "Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the αVβ3 integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.",

keywords = "CELLCYCLE",

author = "Mok, {Samuel C.} and Tomas Bonome and Vinod Vathipadiekal and Aaron Bell and Johnson, {Michael E.} and Wong, {kwong kwok} and Park, {Dong Choon} and Ke Hao and Yip, {Daniel K.P.} and Howard Donninger and Laurent Ozbun and Goli Samimi and John Brady and Mike Randonovich and Pise-Masison, {Cindy A.} and Barrett, {J. Carl} and Wong, {Wing H.} and Welch, {William R.} and Berkowitz, {Ross S.} and Birrer, {Michael J.}",

note = "Funding Information: This study was supported in part by Dana-Farber Ovarian Cancer SPORE grant P50CA105009, R33CA103595, and RO1CA133057 from the National Institutes of Health, Department of Health and Human Services, the Ovarian Cancer Research Fund, Inc., and the Intramural Research Program of the National Institutes of Health, National Cancer Institute. ",

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doi = "10.1016/j.ccr.2009.10.018",

language = "English (US)",

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T1 - A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor

T2 - Microfibril-Associated Glycoprotein 2

AU - Mok, Samuel C.

AU - Bonome, Tomas

AU - Vathipadiekal, Vinod

AU - Bell, Aaron

AU - Johnson, Michael E.

AU - Wong, kwong kwok

AU - Park, Dong Choon

AU - Hao, Ke

AU - Yip, Daniel K.P.

AU - Donninger, Howard

AU - Ozbun, Laurent

AU - Samimi, Goli

AU - Brady, John

AU - Randonovich, Mike

AU - Pise-Masison, Cindy A.

AU - Barrett, J. Carl

AU - Wong, Wing H.

AU - Welch, William R.

AU - Berkowitz, Ross S.

AU - Birrer, Michael J.

N1 - Funding Information: This study was supported in part by Dana-Farber Ovarian Cancer SPORE grant P50CA105009, R33CA103595, and RO1CA133057 from the National Institutes of Health, Department of Health and Human Services, the Ovarian Cancer Research Fund, Inc., and the Intramural Research Program of the National Institutes of Health, National Cancer Institute.

PY - 2009/12/8

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N2 - Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the αVβ3 integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.

AB - Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the αVβ3 integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.

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A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2

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Keywords

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