TY - JOUR
T1 - A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations
AU - Song, Yipeng
AU - Wang, Yang
AU - Xu, Li
AU - Ma, Jinbo
AU - Chen, Ercheng
AU - Zang, Rukun
AU - Jia, Weihua
AU - Tao, Xiaofeng
AU - Hu, Likuan
N1 - Funding Information:
National Natural Science Foundation of China (30671956 and 81270238) and National Natural Science Foundation of Shandong Provence (ZR2012HM083).
Publisher Copyright:
© The Author 2015. Published by Oxford University Press.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Nicotinic acetylcholine receptors are important regulators of smoking behavior and tobacco carcinogenesis. We studied the association of the CHRNB3-A6 variant rs13280604 in relation to esophageal squamous cell carcinoma (ESCC) in Chinese populations. Two independent case-control studies were conducted. The first case-control study, consisted of 866 ESCC patients and 1621 healthy controls from Northern China, and the second case-control study consisted of 853 ESCC patients and 860 unrelated controls from Southern China. A logistic regression model was used to evaluate the associations of rs13280604 with cancer risk. We found that Rs13280604 GG/AG genotypes were significantly associated with increased risk for ESCC in both case-control studies from Northern [odds ratio (OR), 1.42, 95% confidence interval (CI), 1.19-1.70, P = 1.1×10-4], Southern China (OR, 1.56, 95% CI, 1.26-1.93, P = 5.2×10-5), and the combined population of both studies (OR, 1.44, 95% CI, 1.26-1.65, P = 8.7×10-8), respectively. Our results suggest that this CHRNB3-A6 variant confers susceptibility to ESCC risk. However, future larger studies are needed to validate our finding.
AB - Nicotinic acetylcholine receptors are important regulators of smoking behavior and tobacco carcinogenesis. We studied the association of the CHRNB3-A6 variant rs13280604 in relation to esophageal squamous cell carcinoma (ESCC) in Chinese populations. Two independent case-control studies were conducted. The first case-control study, consisted of 866 ESCC patients and 1621 healthy controls from Northern China, and the second case-control study consisted of 853 ESCC patients and 860 unrelated controls from Southern China. A logistic regression model was used to evaluate the associations of rs13280604 with cancer risk. We found that Rs13280604 GG/AG genotypes were significantly associated with increased risk for ESCC in both case-control studies from Northern [odds ratio (OR), 1.42, 95% confidence interval (CI), 1.19-1.70, P = 1.1×10-4], Southern China (OR, 1.56, 95% CI, 1.26-1.93, P = 5.2×10-5), and the combined population of both studies (OR, 1.44, 95% CI, 1.26-1.65, P = 8.7×10-8), respectively. Our results suggest that this CHRNB3-A6 variant confers susceptibility to ESCC risk. However, future larger studies are needed to validate our finding.
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U2 - 10.1093/carcin/bgv019
DO - 10.1093/carcin/bgv019
M3 - Article
C2 - 25823894
AN - SCOPUS:84929173803
SN - 0143-3334
VL - 36
SP - 538
EP - 542
JO - Carcinogenesis
JF - Carcinogenesis
IS - 5
ER -