A Glaucoma-Associated variant of optineurin, M98K, activates Tbk1 to enhance autophagosome formation and retinal cell death dependent on Ser177 phosphorylation of optineurin

Medicine & Life Sciences

• Autophagosomes 87%
• Glaucoma 68%
• Cell Death 54%
• Phosphorylation 49%
• Autophagic Cell Death 41%
• Autophagy 41%
• Transferrin Receptors 35%
• Low Tension Glaucoma 20%
• Starvation 15%
• Missense Mutation 14%
• Ubiquitin 14%
• Caspase 3 12%
• Proteins 5%

Agriculture & Biology

• glaucoma 100%
• cell death 67%
• phosphorylation 62%
• autophagy 61%
• transferrin receptors 30%
• cells 16%
• chemical inhibitors 15%
• missense mutation 13%
• caspase-3 12%
• degradation 12%
• ubiquitin 11%
• catalytic activity 9%
• starvation 9%
• death 7%
• proteins 3%

Chemistry

• Retinal 82%
• Cell Death 76%
• Mutation 8%
• Protein 4%