A guideline on the molecular ecosystem regulating ferroptosis

Enyong Dai; Xin Chen; Andreas Linkermann; Xuejun Jiang; Rui Kang; Valerian E. Kagan; Hülya Bayir; Wan Seok Yang; Ana Garcia-Saez; Maria S. Ioannou; Tobias Janowitz; Qitao Ran; Wei Gu; Boyi Gan; Dmitri V. Krysko; Xiaofeng Zhu; Jiayi Wang; Stefan Krautwald; Shinya Toyokuni; Yangchun Xie; Florian R. Greten; Qing Yi; Joel Schick; Jiao Liu; Dmitry I. Gabrilovich; Jinbao Liu; Herbert J. Zeh; Donna D. Zhang; Minghua Yang; Juan Iovanna; Manfred Kopf; Timon E. Adolph; Jen Tsan Chi; Changfeng Li; Hidenori Ichijo; Michael Karin; Vijay G. Sankaran; Weiping Zou; Lorenzo Galluzzi; Ashley I. Bush; Binghui Li; Gerry Melino; Eric H. Baehrecke; Michael T. Lotze; Daniel J. Klionsky; Brent R. Stockwell; Guido Kroemer; Daolin Tang

doi:10.1038/s41556-024-01360-8

A guideline on the molecular ecosystem regulating ferroptosis

Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E. Kagan, Hülya Bayir, Wan Seok Yang, Ana Garcia-Saez, Maria S. Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V. Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun XieFlorian R. Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I. Gabrilovich, Jinbao Liu, Herbert J. Zeh, Donna D. Zhang, Minghua Yang, Juan Iovanna, Manfred Kopf, Timon E. Adolph, Jen Tsan Chi, Changfeng Li, Hidenori Ichijo, Michael Karin, Vijay G. Sankaran, Weiping Zou, Lorenzo Galluzzi, Ashley I. Bush, Binghui Li, Gerry Melino, Eric H. Baehrecke, Michael T. Lotze, Daniel J. Klionsky, Brent R. Stockwell, Guido Kroemer, Daolin Tang

Experimental Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.

Original language	English (US)
Journal	Nature cell biology
DOIs	https://doi.org/10.1038/s41556-024-01360-8
State	Accepted/In press - 2024

ASJC Scopus subject areas

Cell Biology

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Dai, E., Chen, X., Linkermann, A., Jiang, X., Kang, R., Kagan, V. E., Bayir, H., Yang, W. S., Garcia-Saez, A., Ioannou, M. S., Janowitz, T., Ran, Q., Gu, W., Gan, B., Krysko, D. V., Zhu, X., Wang, J., Krautwald, S., Toyokuni, S., ... Tang, D. (Accepted/In press). A guideline on the molecular ecosystem regulating ferroptosis. Nature cell biology. https://doi.org/10.1038/s41556-024-01360-8

Dai, E, Chen, X, Linkermann, A, Jiang, X, Kang, R, Kagan, VE, Bayir, H, Yang, WS, Garcia-Saez, A, Ioannou, MS, Janowitz, T, Ran, Q, Gu, W, Gan, B, Krysko, DV, Zhu, X, Wang, J, Krautwald, S, Toyokuni, S, Xie, Y, Greten, FR, Yi, Q, Schick, J, Liu, J, Gabrilovich, DI, Liu, J, Zeh, HJ, Zhang, DD, Yang, M, Iovanna, J, Kopf, M, Adolph, TE, Chi, JT, Li, C, Ichijo, H, Karin, M, Sankaran, VG, Zou, W, Galluzzi, L, Bush, AI, Li, B, Melino, G, Baehrecke, EH, Lotze, MT, Klionsky, DJ, Stockwell, BR, Kroemer, G & Tang, D 2024, 'A guideline on the molecular ecosystem regulating ferroptosis', Nature cell biology. https://doi.org/10.1038/s41556-024-01360-8

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title = "A guideline on the molecular ecosystem regulating ferroptosis",

abstract = "Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.",

author = "Enyong Dai and Xin Chen and Andreas Linkermann and Xuejun Jiang and Rui Kang and Kagan, {Valerian E.} and H{\"u}lya Bayir and Yang, {Wan Seok} and Ana Garcia-Saez and Ioannou, {Maria S.} and Tobias Janowitz and Qitao Ran and Wei Gu and Boyi Gan and Krysko, {Dmitri V.} and Xiaofeng Zhu and Jiayi Wang and Stefan Krautwald and Shinya Toyokuni and Yangchun Xie and Greten, {Florian R.} and Qing Yi and Joel Schick and Jiao Liu and Gabrilovich, {Dmitry I.} and Jinbao Liu and Zeh, {Herbert J.} and Zhang, {Donna D.} and Minghua Yang and Juan Iovanna and Manfred Kopf and Adolph, {Timon E.} and Chi, {Jen Tsan} and Changfeng Li and Hidenori Ichijo and Michael Karin and Sankaran, {Vijay G.} and Weiping Zou and Lorenzo Galluzzi and Bush, {Ashley I.} and Binghui Li and Gerry Melino and Baehrecke, {Eric H.} and Lotze, {Michael T.} and Klionsky, {Daniel J.} and Stockwell, {Brent R.} and Guido Kroemer and Daolin Tang",

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year = "2024",

doi = "10.1038/s41556-024-01360-8",

language = "English (US)",

journal = "Nature cell biology",

issn = "1465-7392",

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AU - Dai, Enyong

AU - Chen, Xin

AU - Linkermann, Andreas

AU - Jiang, Xuejun

AU - Kang, Rui

AU - Kagan, Valerian E.

AU - Bayir, Hülya

AU - Yang, Wan Seok

AU - Garcia-Saez, Ana

AU - Ioannou, Maria S.

AU - Janowitz, Tobias

AU - Ran, Qitao

AU - Gu, Wei

AU - Gan, Boyi

AU - Krysko, Dmitri V.

AU - Zhu, Xiaofeng

AU - Wang, Jiayi

AU - Krautwald, Stefan

AU - Toyokuni, Shinya

AU - Xie, Yangchun

AU - Greten, Florian R.

AU - Yi, Qing

AU - Schick, Joel

AU - Liu, Jiao

AU - Gabrilovich, Dmitry I.

AU - Liu, Jinbao

AU - Zeh, Herbert J.

AU - Zhang, Donna D.

AU - Yang, Minghua

AU - Iovanna, Juan

AU - Kopf, Manfred

AU - Adolph, Timon E.

AU - Chi, Jen Tsan

AU - Li, Changfeng

AU - Ichijo, Hidenori

AU - Karin, Michael

AU - Sankaran, Vijay G.

AU - Zou, Weiping

AU - Galluzzi, Lorenzo

AU - Bush, Ashley I.

AU - Li, Binghui

AU - Melino, Gerry

AU - Baehrecke, Eric H.

AU - Lotze, Michael T.

AU - Klionsky, Daniel J.

AU - Stockwell, Brent R.

AU - Kroemer, Guido

AU - Tang, Daolin

PY - 2024

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JO - Nature cell biology

JF - Nature cell biology

ER -

A guideline on the molecular ecosystem regulating ferroptosis

Abstract

ASJC Scopus subject areas

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