@article{cc88238603bc4456a3fe96ddba73e115,
title = "A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice",
abstract = "The ability of the human A375 melanoma cell line to produce experimental and spontaneous metastases in young BALB/c nude mice was examined. Cloned lines, obtained by isolation in semisolid agar, differed significantly (4/10 cloned lines examined, P≤.005) from the parent tumor line with regard to their ability to form lung tumor nodules subsequent to iv injection. Lines established from such lung tumor nodules were more metastatic than the parent line following both iv and sc injection. These results show that the human melanoma cell line used in these studies contained cells with diverse metastatic potential and suggest that metastasis in the nude mouse results from the preferential selection of metastatic subpopulations.",
author = "Kozlowski, {James M.} and Hart, {Ian R.} and Fidler, {Isaiah J.} and Nabil Hanna",
note = "Funding Information: I Received August 5, 1983; accepted November 30, 1983. 2 Research sponsored by the National Cancer Institute, U.S. De partment of Health and Human Services, under contract NOICO-23909 with Litton Bionetics, Inc. 3 The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. 4 Animals were maintained under the guidelines St{"}t forth by the National Institutes of Health Policy on Humane Care and Use of Animals and by the Animal Welfare Act and in facilities recognized by the American Association for Accreditation of Laboratory Animal Care. S Cancer Metastasis and Treatment Laboratory, LBI-Basic Research Program, NCI-Frederick Cancer Research Facility, P.O. Box B, Frederick, Maryland 21701. 6 A Burroughs Wellcome Scholar of the American Urological Association and a Leander Riba Fellow of Northwestern University Medical School. 7 Address reprint requests to Dr. Hart at his present address: Imperial Cancer Research Fund Laboratories, P.O. Box 123, Lincoln's Inn Fields, London, WC2A 3PX, England. 8 Smith Kline and French Laboratories, 620 Allendale Rd., King of Prussia, Pa. 19406.",
year = "1984",
month = apr,
doi = "10.1093/jnci/72.4.913",
language = "English (US)",
volume = "72",
pages = "913--917",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "4",
}