A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene

Nelson Wohllk; Pamela M. Thomas; Eileen Huang; Gilbert J. Cote

doi:10.1006/mgme.1998.2752

A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene

Nelson Wohllk, Pamela M. Thomas, Eileen Huang, Gilbert J. Cote

Endocrine Neoplasia & HD

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We report the cloning of two variant genes encoding the CII-3 subunit of succinate-ubiquinone oxidoreductase complex II. One gene is located within intron 10 of the human sulfonylurea receptor gene. The 3' boundary of this gene ends in a polymorphic dinucleotide repeat. The second gene CII-3b is expressed at a low level and contains a 102-bp internal deletion compared to CII-3 cDNA. These genes should prove valuable in the characterization of Complex II disorders.

Original language	English (US)
Pages (from-to)	187-190
Number of pages	4
Journal	Molecular Genetics and Metabolism
Volume	65
Issue number	3
DOIs	https://doi.org/10.1006/mgme.1998.2752
State	Published - Nov 1998

Keywords

CII-3 subunit
Complex II
Polymorphic repeat
Sulfonylurea receptor

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
Genetics
Endocrinology

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10.1006/mgme.1998.2752

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title = "A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene",

abstract = "We report the cloning of two variant genes encoding the CII-3 subunit of succinate-ubiquinone oxidoreductase complex II. One gene is located within intron 10 of the human sulfonylurea receptor gene. The 3' boundary of this gene ends in a polymorphic dinucleotide repeat. The second gene CII-3b is expressed at a low level and contains a 102-bp internal deletion compared to CII-3 cDNA. These genes should prove valuable in the characterization of Complex II disorders.",

keywords = "CII-3 subunit, Complex II, Polymorphic repeat, Sulfonylurea receptor",

author = "Nelson Wohllk and Thomas, {Pamela M.} and Eileen Huang and Cote, {Gilbert J.}",

note = "Funding Information: This work was supported by NIH Grant CA67946 (G.J.C.) and JDFI Award 195104 (P.M.T.). In addition, we thank the DNA Core Sequence Facility for sequencing. The facility is supported by NIH Grant CA16672.",

year = "1998",

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doi = "10.1006/mgme.1998.2752",

language = "English (US)",

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AU - Wohllk, Nelson

AU - Thomas, Pamela M.

AU - Huang, Eileen

AU - Cote, Gilbert J.

N1 - Funding Information: This work was supported by NIH Grant CA67946 (G.J.C.) and JDFI Award 195104 (P.M.T.). In addition, we thank the DNA Core Sequence Facility for sequencing. The facility is supported by NIH Grant CA16672.

PY - 1998/11

Y1 - 1998/11

N2 - We report the cloning of two variant genes encoding the CII-3 subunit of succinate-ubiquinone oxidoreductase complex II. One gene is located within intron 10 of the human sulfonylurea receptor gene. The 3' boundary of this gene ends in a polymorphic dinucleotide repeat. The second gene CII-3b is expressed at a low level and contains a 102-bp internal deletion compared to CII-3 cDNA. These genes should prove valuable in the characterization of Complex II disorders.

AB - We report the cloning of two variant genes encoding the CII-3 subunit of succinate-ubiquinone oxidoreductase complex II. One gene is located within intron 10 of the human sulfonylurea receptor gene. The 3' boundary of this gene ends in a polymorphic dinucleotide repeat. The second gene CII-3b is expressed at a low level and contains a 102-bp internal deletion compared to CII-3 cDNA. These genes should prove valuable in the characterization of Complex II disorders.

KW - CII-3 subunit

KW - Complex II

KW - Polymorphic repeat

KW - Sulfonylurea receptor

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A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene

Abstract

Keywords

ASJC Scopus subject areas

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