A longitudinal study of T and B lymphocytes from a three year old patient with severe combined immunodeficiency (SCID) in 'gnotobiotic protection'

N. Mukhopadhyay, Ellen R Richie, B. F. Mackler, J. R. Montgomery, R. Wilson, D. J. Fernbach, M. A. South

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Fluctuations in the percentages and absolute numbers of T and B lymphocytes were observed in the peripheral blood of a patient with severe combined immunodeficiency maintained in a gnotobiotic environment. Up to 24 mth of age, 72-86% of the lymphocytes had surface membrane immunoglobulin (SMIg), 37-47% bore a receptor for C3(EAC-RFC), and 3-12.5% formed spontaneous rosettes with sheep erythrocytes (E-RFC). These values persisted until 30 mth, after which shifts in the percentages and absolute numbers of T and B cells were observed. A significant decrease in the proportion of SMIg-bearing cells to 20-40% (169-405 mm 3), and EAC-RFC to 10.5-39% (114-259 mm 3), was accompanied by a general increase in the proportion of T cells to 19-60% (141-1026 mm 3), representing a lymphoid subpopulation approach to normal levels.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalExperimental Hematology
Volume6
Issue number2
StatePublished - Sep 22 1978

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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    Mukhopadhyay, N., Richie, E. R., Mackler, B. F., Montgomery, J. R., Wilson, R., Fernbach, D. J., & South, M. A. (1978). A longitudinal study of T and B lymphocytes from a three year old patient with severe combined immunodeficiency (SCID) in 'gnotobiotic protection'. Experimental Hematology, 6(2), 129-134.