Abstract
Fluctuations in the percentages and absolute numbers of T and B lymphocytes were observed in the peripheral blood of a patient with severe combined immunodeficiency maintained in a gnotobiotic environment. Up to 24 mth of age, 72-86% of the lymphocytes had surface membrane immunoglobulin (SMIg), 37-47% bore a receptor for C3(EAC-RFC), and 3-12.5% formed spontaneous rosettes with sheep erythrocytes (E-RFC). These values persisted until 30 mth, after which shifts in the percentages and absolute numbers of T and B cells were observed. A significant decrease in the proportion of SMIg-bearing cells to 20-40% (169-405 mm 3), and EAC-RFC to 10.5-39% (114-259 mm 3), was accompanied by a general increase in the proportion of T cells to 19-60% (141-1026 mm 3), representing a lymphoid subpopulation approach to normal levels.
Original language | English (US) |
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Pages (from-to) | 129-134 |
Number of pages | 6 |
Journal | Experimental Hematology |
Volume | 6 |
Issue number | 2 |
State | Published - 1978 |
ASJC Scopus subject areas
- Molecular Biology
- Hematology
- Genetics
- Cell Biology
- Cancer Research