TY - JOUR
T1 - A Markov model assessing the effectiveness and cost-effectiveness of FOLFOX compared with FOLFIRI for the initial treatment of metastatic colorectal cancer
AU - Tumeh, John W.
AU - Shenoy, Pareen J.
AU - Moore, Susan G.
AU - Kauh, John
AU - Flowers, Christopher
PY - 2009/2
Y1 - 2009/2
N2 - Objective: To analyze the efficacy and cost-effectiveness of FOLFOX compared with FOLFIRI for patients with metastatic colorectal cancer. Method: We developed a Markov decision model using a hypothetical cohort of patients with metastatic colorectal cancer to compare beginning chemotherapy with FOLFOX or FOLFIRI. Probabilities of toxicities, including neutropenia, diarrhea, and neuropathy, were based on published literature for FOLFOX and FOLFIRI. Costs for physician and hospital services unadjusted for geographic location were estimated using Centers for Medicare and Medicaid services reimbursement data. Drug costs were estimated using Medicare B reimbursement and the Federal Supply Schedule. Health outcomes were measured in quality-adjusted life years (QALYs). Univariate and probabilistic sensitivity analyses were performed to address uncertainty in the model parameters. Results: The FOLFOX strategy provided 1.003 QALYs at a cost of $29,865, whereas FOLFIRI provided 0.921 QALYs at a cost of $24,551. The incremental cost-effectiveness ratio for FOLFOX treatment was $65,170/QALY. In 10,000 probabilistic Monte Carlo simulations, FOLFOX was cost-effective in 48.59% of trials using a $50,000/QALY threshold. The most influential variables in univariate sensitivity analysis were the expected years of survival associated with each chemotherapy regimen. Conclusions: FOLFOX and FOLFIRI are similar in terms of costs and benefits. The slight QALY benefits associated with FOLFOX are within the range of $100,000/QALY, an accepted threshold in oncology.
AB - Objective: To analyze the efficacy and cost-effectiveness of FOLFOX compared with FOLFIRI for patients with metastatic colorectal cancer. Method: We developed a Markov decision model using a hypothetical cohort of patients with metastatic colorectal cancer to compare beginning chemotherapy with FOLFOX or FOLFIRI. Probabilities of toxicities, including neutropenia, diarrhea, and neuropathy, were based on published literature for FOLFOX and FOLFIRI. Costs for physician and hospital services unadjusted for geographic location were estimated using Centers for Medicare and Medicaid services reimbursement data. Drug costs were estimated using Medicare B reimbursement and the Federal Supply Schedule. Health outcomes were measured in quality-adjusted life years (QALYs). Univariate and probabilistic sensitivity analyses were performed to address uncertainty in the model parameters. Results: The FOLFOX strategy provided 1.003 QALYs at a cost of $29,865, whereas FOLFIRI provided 0.921 QALYs at a cost of $24,551. The incremental cost-effectiveness ratio for FOLFOX treatment was $65,170/QALY. In 10,000 probabilistic Monte Carlo simulations, FOLFOX was cost-effective in 48.59% of trials using a $50,000/QALY threshold. The most influential variables in univariate sensitivity analysis were the expected years of survival associated with each chemotherapy regimen. Conclusions: FOLFOX and FOLFIRI are similar in terms of costs and benefits. The slight QALY benefits associated with FOLFOX are within the range of $100,000/QALY, an accepted threshold in oncology.
KW - Colorectal cancer
KW - Cost-effectiveness analysis
KW - Markov model
KW - Quality of life
KW - Quality-adjusted life years
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U2 - 10.1097/COC.0b013e31817c6a4d
DO - 10.1097/COC.0b013e31817c6a4d
M3 - Article
C2 - 19194125
AN - SCOPUS:85047684124
SN - 0277-3732
VL - 32
SP - 49
EP - 55
JO - American Journal of Clinical Oncology: Cancer Clinical Trials
JF - American Journal of Clinical Oncology: Cancer Clinical Trials
IS - 1
ER -