A microRNA component of the hypoxic response

R. Kulshreshtha; R. V. Davuluri; G. A. Calin; M. Ivan

doi:10.1038/sj.cdd.4402310

A microRNA component of the hypoxic response

R. Kulshreshtha, R. V. Davuluri, G. A. Calin, M. Ivan

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

229 Scopus citations

Abstract

microRNAs participate in a wide variety of physiological and pathological cellular processes. Recent studies have established a link between a specific group of microRNAs and hypoxia, a key feature of the neoplastic microenvironment. A significant proportion of the hypoxia-regulated microRNAs (HRMs) are also overexpressed in human cancers, suggesting a role in tumorigenesis. Preliminary evidence suggests that they could affect important processes such as apoptosis, proliferation and angiogenesis. Several HRMs exhibit induction in response to HIF activation, thus extending its repertoire of targets beyond translated genes. In the present review, we discuss the emerging roles of HRMs in oxygen deprivation in cancer context.

Original language	English (US)
Pages (from-to)	667-671
Number of pages	5
Journal	Cell death and differentiation
Volume	15
Issue number	4
DOIs	https://doi.org/10.1038/sj.cdd.4402310
State	Published - Apr 2008

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/sj.cdd.4402310

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title = "A microRNA component of the hypoxic response",

abstract = "microRNAs participate in a wide variety of physiological and pathological cellular processes. Recent studies have established a link between a specific group of microRNAs and hypoxia, a key feature of the neoplastic microenvironment. A significant proportion of the hypoxia-regulated microRNAs (HRMs) are also overexpressed in human cancers, suggesting a role in tumorigenesis. Preliminary evidence suggests that they could affect important processes such as apoptosis, proliferation and angiogenesis. Several HRMs exhibit induction in response to HIF activation, thus extending its repertoire of targets beyond translated genes. In the present review, we discuss the emerging roles of HRMs in oxygen deprivation in cancer context.",

author = "R. Kulshreshtha and Davuluri, {R. V.} and Calin, {G. A.} and M. Ivan",

note = "Funding Information: Acknowledgements. This work was supported by the NIH Grant P30 DK-34928 and AACR/PanCan career development award to MI; Kimmel Scholar award to GAC; RD is supported by grants from National Cancer Institute (Project 3 of U54CA113001), National Human Genome Research Institute (R01HG003362) and American Cancer Society (RSG-06-268-01).",

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AU - Kulshreshtha, R.

AU - Davuluri, R. V.

AU - Calin, G. A.

AU - Ivan, M.

N1 - Funding Information: Acknowledgements. This work was supported by the NIH Grant P30 DK-34928 and AACR/PanCan career development award to MI; Kimmel Scholar award to GAC; RD is supported by grants from National Cancer Institute (Project 3 of U54CA113001), National Human Genome Research Institute (R01HG003362) and American Cancer Society (RSG-06-268-01).

PY - 2008/4

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N2 - microRNAs participate in a wide variety of physiological and pathological cellular processes. Recent studies have established a link between a specific group of microRNAs and hypoxia, a key feature of the neoplastic microenvironment. A significant proportion of the hypoxia-regulated microRNAs (HRMs) are also overexpressed in human cancers, suggesting a role in tumorigenesis. Preliminary evidence suggests that they could affect important processes such as apoptosis, proliferation and angiogenesis. Several HRMs exhibit induction in response to HIF activation, thus extending its repertoire of targets beyond translated genes. In the present review, we discuss the emerging roles of HRMs in oxygen deprivation in cancer context.

AB - microRNAs participate in a wide variety of physiological and pathological cellular processes. Recent studies have established a link between a specific group of microRNAs and hypoxia, a key feature of the neoplastic microenvironment. A significant proportion of the hypoxia-regulated microRNAs (HRMs) are also overexpressed in human cancers, suggesting a role in tumorigenesis. Preliminary evidence suggests that they could affect important processes such as apoptosis, proliferation and angiogenesis. Several HRMs exhibit induction in response to HIF activation, thus extending its repertoire of targets beyond translated genes. In the present review, we discuss the emerging roles of HRMs in oxygen deprivation in cancer context.

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A microRNA component of the hypoxic response

Abstract

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