A Molecular Take on Malignant Rhabdoid Tumors

Ming Tang; Roel G.W. Verhaak

doi:10.1016/j.trecan.2016.04.003

A Molecular Take on Malignant Rhabdoid Tumors

Ming Tang, Roel G.W. Verhaak

Bioinformatics & Computational Biology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

The molecular basis for the clinical heterogeneity observed in patients with malignant rhabdoid tumors is unknown. Recently, two reports revealed molecular intertumor heterogeneity in teratoid/rhabdoid tumors (ATRTs) and extra-cranial MRTs (ecMRTs) using genomic, transcriptomic, and epigenomic profiling. Distinct molecular subgroups were identified and new therapeutic targets were revealed.

Original language	English (US)
Pages (from-to)	217-218
Number of pages	2
Journal	Trends in Cancer
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/j.trecan.2016.04.003
State	Published - May 1 2016

Keywords

malignant rhabdoid tumors
molecular analysis
pediatric cancer
sequencing

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2016.04.003

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title = "A Molecular Take on Malignant Rhabdoid Tumors",

abstract = "The molecular basis for the clinical heterogeneity observed in patients with malignant rhabdoid tumors is unknown. Recently, two reports revealed molecular intertumor heterogeneity in teratoid/rhabdoid tumors (ATRTs) and extra-cranial MRTs (ecMRTs) using genomic, transcriptomic, and epigenomic profiling. Distinct molecular subgroups were identified and new therapeutic targets were revealed.",

keywords = "malignant rhabdoid tumors, molecular analysis, pediatric cancer, sequencing",

author = "Ming Tang and Verhaak, {Roel G.W.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

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doi = "10.1016/j.trecan.2016.04.003",

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AU - Tang, Ming

AU - Verhaak, Roel G.W.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - The molecular basis for the clinical heterogeneity observed in patients with malignant rhabdoid tumors is unknown. Recently, two reports revealed molecular intertumor heterogeneity in teratoid/rhabdoid tumors (ATRTs) and extra-cranial MRTs (ecMRTs) using genomic, transcriptomic, and epigenomic profiling. Distinct molecular subgroups were identified and new therapeutic targets were revealed.

AB - The molecular basis for the clinical heterogeneity observed in patients with malignant rhabdoid tumors is unknown. Recently, two reports revealed molecular intertumor heterogeneity in teratoid/rhabdoid tumors (ATRTs) and extra-cranial MRTs (ecMRTs) using genomic, transcriptomic, and epigenomic profiling. Distinct molecular subgroups were identified and new therapeutic targets were revealed.

KW - malignant rhabdoid tumors

KW - molecular analysis

KW - pediatric cancer

KW - sequencing

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DO - 10.1016/j.trecan.2016.04.003

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EP - 218

JO - Trends in Cancer

JF - Trends in Cancer

IS - 5

ER -

A Molecular Take on Malignant Rhabdoid Tumors

Abstract

Keywords

ASJC Scopus subject areas

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