TY - JOUR
T1 - A morphological and immunohistochemical comparison of mammary tissues from the short-tailed fruit bat (Carollia perspicillata) and the mouse
AU - Evarts, Jennifer L.
AU - Rasweiler IV, John J.
AU - Behringer, Richard R.
AU - Hennighausen, Lothar
AU - Robinson, Gertraud W.
PY - 2004/6
Y1 - 2004/6
N2 - In the present study, mammary tissues from the fruit bat (Carollia perspicillata) and mouse (Mus musculus) were compared using histological and immunohistochemical methods. Because the female bat exhibits greater reproductive similarities to humans, it might provide a useful animal model for studying mammary physiology and disease with relevance to our own species. In lactating and recently lactating specimens, bat tissue had significantly fewer adipocytes and more collagenous connective tissue compared to the mouse. The proteins Stat5a, keratin 5, Npt2b, and E-cadherin were all similarly localized in mouse and bat mammary tissues taken from lactating animals. The present study demonstrates that whereas the epithelial compartment and the presence of differentiation markers are conserved between the mouse and bat, differences exist in the stromal compartment.
AB - In the present study, mammary tissues from the fruit bat (Carollia perspicillata) and mouse (Mus musculus) were compared using histological and immunohistochemical methods. Because the female bat exhibits greater reproductive similarities to humans, it might provide a useful animal model for studying mammary physiology and disease with relevance to our own species. In lactating and recently lactating specimens, bat tissue had significantly fewer adipocytes and more collagenous connective tissue compared to the mouse. The proteins Stat5a, keratin 5, Npt2b, and E-cadherin were all similarly localized in mouse and bat mammary tissues taken from lactating animals. The present study demonstrates that whereas the epithelial compartment and the presence of differentiation markers are conserved between the mouse and bat, differences exist in the stromal compartment.
KW - Developmental biology
KW - Mammary glands
UR - http://www.scopus.com/inward/record.url?scp=2642519631&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2642519631&partnerID=8YFLogxK
U2 - 10.1095/biolreprod.103.022988
DO - 10.1095/biolreprod.103.022988
M3 - Article
C2 - 14749297
AN - SCOPUS:2642519631
SN - 0006-3363
VL - 70
SP - 1573
EP - 1579
JO - Biology of reproduction
JF - Biology of reproduction
IS - 6
ER -