TY - JOUR
T1 - A mouse c-ros genomic clone
T2 - identification of a highly conserved 22-amino acid segment in the juxtamembrane domain
AU - Narayana, Lakshmi
AU - Nagarajan, Lalitha
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/9/10
Y1 - 1992/9/10
N2 - The mouse c-ros protooncogene genomic sequences have been cloned; an analysis of the partial genomic clone revealed a high conservation of the exons encoding the juxtamembrane (JM) and the 5' most protein tyrosine kinase domains. We have identified a segment of 22 amino acids conserved between the human and mouse JM domains; this segment may have a critical role in the function of the c-ros-encoded protein tyrosine kinase receptor.
AB - The mouse c-ros protooncogene genomic sequences have been cloned; an analysis of the partial genomic clone revealed a high conservation of the exons encoding the juxtamembrane (JM) and the 5' most protein tyrosine kinase domains. We have identified a segment of 22 amino acids conserved between the human and mouse JM domains; this segment may have a critical role in the function of the c-ros-encoded protein tyrosine kinase receptor.
KW - Murine/human homology
KW - chicken
KW - protein tyrosine kinase receptor
KW - protooncogene, Drosophila melanogaster sevenless gene
UR - http://www.scopus.com/inward/record.url?scp=0026669697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026669697&partnerID=8YFLogxK
U2 - 10.1016/0378-1119(92)90205-4
DO - 10.1016/0378-1119(92)90205-4
M3 - Article
C2 - 1324876
AN - SCOPUS:0026669697
SN - 0378-1119
VL - 118
SP - 297
EP - 298
JO - Gene
JF - Gene
IS - 2
ER -