A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks

R. Scott Williams; John A. Tainer

doi:10.1016/j.molcel.2005.07.006

A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks

R. Scott Williams, John A. Tainer

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

In a recent study (Moreno-Herrero et al., 2005), atomic force microscopy (AFM) imaging of the human Mre11/Rad50/Nbs1 (MRN) complex engaging substrate DNA revealed large-scale, DNA binding-induced propagation of conformational change to the distal ends of the Rad50 coiled coils and erection of a 1000 Å scaffold to productively bridge DNA ends.

Original language	English (US)
Pages (from-to)	724-726
Number of pages	3
Journal	Molecular cell
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2005.07.006
State	Published - Sep 16 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2005.07.006

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abstract = "In a recent study (Moreno-Herrero et al., 2005), atomic force microscopy (AFM) imaging of the human Mre11/Rad50/Nbs1 (MRN) complex engaging substrate DNA revealed large-scale, DNA binding-induced propagation of conformational change to the distal ends of the Rad50 coiled coils and erection of a 1000 {\AA} scaffold to productively bridge DNA ends.",

author = "Williams, {R. Scott} and Tainer, {John A.}",

year = "2005",

month = sep,

day = "16",

doi = "10.1016/j.molcel.2005.07.006",

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AU - Williams, R. Scott

AU - Tainer, John A.

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N2 - In a recent study (Moreno-Herrero et al., 2005), atomic force microscopy (AFM) imaging of the human Mre11/Rad50/Nbs1 (MRN) complex engaging substrate DNA revealed large-scale, DNA binding-induced propagation of conformational change to the distal ends of the Rad50 coiled coils and erection of a 1000 Å scaffold to productively bridge DNA ends.

AB - In a recent study (Moreno-Herrero et al., 2005), atomic force microscopy (AFM) imaging of the human Mre11/Rad50/Nbs1 (MRN) complex engaging substrate DNA revealed large-scale, DNA binding-induced propagation of conformational change to the distal ends of the Rad50 coiled coils and erection of a 1000 Å scaffold to productively bridge DNA ends.

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JO - Molecular cell

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A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks

Abstract

ASJC Scopus subject areas

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