TY - JOUR
T1 - A new heat source for thermochemical ablation based on redox chemistry
T2 - Initial studies using permanganate
AU - Cressman, Erik N.K.
AU - Tseng, Hsiang Jer
AU - Talaie, Reza
AU - Henderson, Brett M.
N1 - Funding Information:
Declaration of interest: This research was supported in part by a grant from the Ernest J. Ring Faculty Development Award from the society of Interventional Radiology Foundation.
PY - 2010
Y1 - 2010
N2 - Purpose: To evaluate exothermic permanganate redox chemistry for utility in tumour ablation. Materials and methods: Sodium permanganate (13 mL, 1 or 2 M) and glycerol (1 mL, 1 M) were injected in triplicate into a beaker using three injection orders: (1) simultaneous, (2) glycerol injection then permanganate injection, (3) permanganate injection then glycerol injection. Selected experiments were repeated with glucose, sucrose, dextrin, maltodextrin, different polysaccharides, and polyvinyl alcohol as substrates. Simultaneous injections of permanganate (0.5 and 1 mL, 2 M) and glucose (1 mL, 1 M) into explanted porcine muscle were also performed. Temperatures were recorded with a thermocouple probe or an infrared camera. Results: With optimal conditions of 2 M permanganate and 1 M glycerol at 1 mL each, an average maximum temperature of 97.4°C was obtained for all three injection orders. When glucose and sucrose were used as the substrates, similar temperatures were achieved but at different rates. Dextrin and maltodextrin (180 g/L) led to maximum temperatures of 42.5° and 51.1°C respectively when simultaneously injected with permanganate (1 mL, 2 M). Polysaccharides and polyvinyl alcohols under the same conditions resulted in a minimal temperature increase. Intramuscular injections of glucose (0.5 mL, 1 M) and permanganate (0.5 mL, 2 M) reached an average temperature of 76.5°C at the lesion site. Conclusions: The permanganate redox reaction is a powerful system with potential to reach tumouricidal temperatures. The reagent volumes, concentrations, injection order, and substrate choice allow a measure of control over the reaction.
AB - Purpose: To evaluate exothermic permanganate redox chemistry for utility in tumour ablation. Materials and methods: Sodium permanganate (13 mL, 1 or 2 M) and glycerol (1 mL, 1 M) were injected in triplicate into a beaker using three injection orders: (1) simultaneous, (2) glycerol injection then permanganate injection, (3) permanganate injection then glycerol injection. Selected experiments were repeated with glucose, sucrose, dextrin, maltodextrin, different polysaccharides, and polyvinyl alcohol as substrates. Simultaneous injections of permanganate (0.5 and 1 mL, 2 M) and glucose (1 mL, 1 M) into explanted porcine muscle were also performed. Temperatures were recorded with a thermocouple probe or an infrared camera. Results: With optimal conditions of 2 M permanganate and 1 M glycerol at 1 mL each, an average maximum temperature of 97.4°C was obtained for all three injection orders. When glucose and sucrose were used as the substrates, similar temperatures were achieved but at different rates. Dextrin and maltodextrin (180 g/L) led to maximum temperatures of 42.5° and 51.1°C respectively when simultaneously injected with permanganate (1 mL, 2 M). Polysaccharides and polyvinyl alcohols under the same conditions resulted in a minimal temperature increase. Intramuscular injections of glucose (0.5 mL, 1 M) and permanganate (0.5 mL, 2 M) reached an average temperature of 76.5°C at the lesion site. Conclusions: The permanganate redox reaction is a powerful system with potential to reach tumouricidal temperatures. The reagent volumes, concentrations, injection order, and substrate choice allow a measure of control over the reaction.
KW - Hepatocellular carcinoma
KW - Hyperthermia
KW - Oxidation
KW - Permanganate
KW - Reduction
KW - Thermochemical ablation
UR - http://www.scopus.com/inward/record.url?scp=77952469971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952469971&partnerID=8YFLogxK
U2 - 10.3109/02656731003614516
DO - 10.3109/02656731003614516
M3 - Article
C2 - 20345271
AN - SCOPUS:77952469971
SN - 0265-6736
VL - 26
SP - 327
EP - 337
JO - International Journal of Hyperthermia
JF - International Journal of Hyperthermia
IS - 4
ER -