A new method for gene functional prediction based on homologous expression profile

Sali Lv; Qianghu Wang; Guangmei Zhang; Fengxia Wen; Zhenzhen Wang; Xia Li

doi:10.1007/11540007_104

A new method for gene functional prediction based on homologous expression profile

Sali Lv, Qianghu Wang, Guangmei Zhang, Fengxia Wen, Zhenzhen Wang, Xia Li

Bioinformatics & Computational Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

It is a project with significant challenge to predict functions of genes in the post-genomics era. Most function annotation systems is available to predict functions of part genes, but the rate of annotation is very low and a large number of genes can not be annotated, what's more, the measure of credibility isn't quite sure. Aiming at the problem, we address the new concept of functional expression profile using knowledge system existed, and consider the method of gene cluster mapping associated with hub genes to predict functions of genes which are not still annotated based on the association between gene expression and gene function. At last we applied the method to colon data set. The results implied the prediction efficiency and credibility have been improved significantly by the method.

Original language	English (US)
Title of host publication	Fuzzy Systems and Knowledge Discovery - Second International Conference, FSKD 2005, Proceedings
Publisher	Springer Verlag
Pages	836-844
Number of pages	9
ISBN (Print)	9783540283317
DOIs	https://doi.org/10.1007/11540007_104
State	Published - 2006
Event	2nd International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2005 - Changsa, China Duration: Aug 27 2005 → Aug 29 2005

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	3614 LNAI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	2nd International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2005
Country/Territory	China
City	Changsa
Period	8/27/05 → 8/29/05

ASJC Scopus subject areas

Theoretical Computer Science
General Computer Science

Access to Document

10.1007/11540007_104

Cite this

Lv, S., Wang, Q., Zhang, G., Wen, F., Wang, Z., & Li, X. (2006). A new method for gene functional prediction based on homologous expression profile. In Fuzzy Systems and Knowledge Discovery - Second International Conference, FSKD 2005, Proceedings (pp. 836-844). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 3614 LNAI). Springer Verlag. https://doi.org/10.1007/11540007_104

A new method for gene functional prediction based on homologous expression profile. / Lv, Sali; Wang, Qianghu; Zhang, Guangmei et al.
Fuzzy Systems and Knowledge Discovery - Second International Conference, FSKD 2005, Proceedings. Springer Verlag, 2006. p. 836-844 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 3614 LNAI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lv, S, Wang, Q, Zhang, G, Wen, F, Wang, Z & Li, X 2006, A new method for gene functional prediction based on homologous expression profile. in Fuzzy Systems and Knowledge Discovery - Second International Conference, FSKD 2005, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 3614 LNAI, Springer Verlag, pp. 836-844, 2nd International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2005, Changsa, China, 8/27/05. https://doi.org/10.1007/11540007_104

Lv S, Wang Q, Zhang G, Wen F, Wang Z, Li X. A new method for gene functional prediction based on homologous expression profile. In Fuzzy Systems and Knowledge Discovery - Second International Conference, FSKD 2005, Proceedings. Springer Verlag. 2006. p. 836-844. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/11540007_104

Lv, Sali ; Wang, Qianghu ; Zhang, Guangmei et al. / A new method for gene functional prediction based on homologous expression profile. Fuzzy Systems and Knowledge Discovery - Second International Conference, FSKD 2005, Proceedings. Springer Verlag, 2006. pp. 836-844 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

@inproceedings{40011caec0ca47fcaf40c4a4ff3a8476,

title = "A new method for gene functional prediction based on homologous expression profile",

abstract = "It is a project with significant challenge to predict functions of genes in the post-genomics era. Most function annotation systems is available to predict functions of part genes, but the rate of annotation is very low and a large number of genes can not be annotated, what's more, the measure of credibility isn't quite sure. Aiming at the problem, we address the new concept of functional expression profile using knowledge system existed, and consider the method of gene cluster mapping associated with hub genes to predict functions of genes which are not still annotated based on the association between gene expression and gene function. At last we applied the method to colon data set. The results implied the prediction efficiency and credibility have been improved significantly by the method.",

author = "Sali Lv and Qianghu Wang and Guangmei Zhang and Fengxia Wen and Zhenzhen Wang and Xia Li",

note = "Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 2nd International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2005 ; Conference date: 27-08-2005 Through 29-08-2005",

year = "2006",

doi = "10.1007/11540007_104",

language = "English (US)",

isbn = "9783540283317",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

publisher = "Springer Verlag",

pages = "836--844",

booktitle = "Fuzzy Systems and Knowledge Discovery - Second International Conference, FSKD 2005, Proceedings",

}

TY - GEN

T1 - A new method for gene functional prediction based on homologous expression profile

AU - Lv, Sali

AU - Wang, Qianghu

AU - Zhang, Guangmei

AU - Wen, Fengxia

AU - Wang, Zhenzhen

AU - Li, Xia

PY - 2006

Y1 - 2006

N2 - It is a project with significant challenge to predict functions of genes in the post-genomics era. Most function annotation systems is available to predict functions of part genes, but the rate of annotation is very low and a large number of genes can not be annotated, what's more, the measure of credibility isn't quite sure. Aiming at the problem, we address the new concept of functional expression profile using knowledge system existed, and consider the method of gene cluster mapping associated with hub genes to predict functions of genes which are not still annotated based on the association between gene expression and gene function. At last we applied the method to colon data set. The results implied the prediction efficiency and credibility have been improved significantly by the method.

AB - It is a project with significant challenge to predict functions of genes in the post-genomics era. Most function annotation systems is available to predict functions of part genes, but the rate of annotation is very low and a large number of genes can not be annotated, what's more, the measure of credibility isn't quite sure. Aiming at the problem, we address the new concept of functional expression profile using knowledge system existed, and consider the method of gene cluster mapping associated with hub genes to predict functions of genes which are not still annotated based on the association between gene expression and gene function. At last we applied the method to colon data set. The results implied the prediction efficiency and credibility have been improved significantly by the method.

UR - http://www.scopus.com/inward/record.url?scp=33749005932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749005932&partnerID=8YFLogxK

U2 - 10.1007/11540007_104

DO - 10.1007/11540007_104

M3 - Conference contribution

AN - SCOPUS:33749005932

SN - 9783540283317

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 836

EP - 844

BT - Fuzzy Systems and Knowledge Discovery - Second International Conference, FSKD 2005, Proceedings

PB - Springer Verlag

T2 - 2nd International Conference on Fuzzy Systems and Knowledge Discovery, FSKD 2005

Y2 - 27 August 2005 through 29 August 2005

ER -

A new method for gene functional prediction based on homologous expression profile

Abstract

Publication series

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this