A New Small-Molecule Stat3 Inhibitor

John S. McMurray

doi:10.1016/j.chembiol.2006.11.001

A New Small-Molecule Stat3 Inhibitor

John S. McMurray

Experimental Therapeutics

Research output: Contribution to journal › Short survey › peer-review

72 Scopus citations

Abstract

In this issue of Chemistry & Biology, Schust et al. [1] report the discovery of a small molecule (Stattic) that inhibits the binding of a high affinity phosphopeptide for the SH2 domain of Stat3. Stattic is a new tool for studying Stat3 signaling and demonstrates that the SH2 domain is not a dead target.

Original language	English (US)
Pages (from-to)	1123-1124
Number of pages	2
Journal	Chemistry and Biology
Volume	13
Issue number	11
DOIs	https://doi.org/10.1016/j.chembiol.2006.11.001
State	Published - Nov 2006

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2006.11.001

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title = "A New Small-Molecule Stat3 Inhibitor",

abstract = "In this issue of Chemistry & Biology, Schust et al. [1] report the discovery of a small molecule (Stattic) that inhibits the binding of a high affinity phosphopeptide for the SH2 domain of Stat3. Stattic is a new tool for studying Stat3 signaling and demonstrates that the SH2 domain is not a dead target.",

author = "McMurray, {John S.}",

year = "2006",

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doi = "10.1016/j.chembiol.2006.11.001",

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volume = "13",

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journal = "Chemistry and Biology",

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AU - McMurray, John S.

PY - 2006/11

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N2 - In this issue of Chemistry & Biology, Schust et al. [1] report the discovery of a small molecule (Stattic) that inhibits the binding of a high affinity phosphopeptide for the SH2 domain of Stat3. Stattic is a new tool for studying Stat3 signaling and demonstrates that the SH2 domain is not a dead target.

AB - In this issue of Chemistry & Biology, Schust et al. [1] report the discovery of a small molecule (Stattic) that inhibits the binding of a high affinity phosphopeptide for the SH2 domain of Stat3. Stattic is a new tool for studying Stat3 signaling and demonstrates that the SH2 domain is not a dead target.

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U2 - 10.1016/j.chembiol.2006.11.001

DO - 10.1016/j.chembiol.2006.11.001

M3 - Short survey

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AN - SCOPUS:33750985364

SN - 1074-5521

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SP - 1123

EP - 1124

JO - Chemistry and Biology

JF - Chemistry and Biology

IS - 11

ER -

A New Small-Molecule Stat3 Inhibitor

Abstract

ASJC Scopus subject areas

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