A nonlethal murine cutaneous model of invasive aspergillosis

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Cutaneous models allow researchers to dynamically monitor infection by visually determining changes in skin lesion dimensions over time. We present a nonlethal cutaneous model of invasive aspergillosis (IA) in nude BALB/c mice and describe its use to determine altered virulence in Aspergillus strains and response to antifungal drugs. In addition, as an example of the versatility of this model, we show how the cutaneous model can be used to assess the effect of IA on angiogenesis in vivo.

Original languageEnglish (US)
Title of host publicationHost-Fungus Interactions
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages569-582
Number of pages14
ISBN (Print)9781617795381
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume845
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Angiogenesis
  • Aspergillosis
  • Cutaneous
  • Drug
  • Model
  • Virulence

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint

Dive into the research topics of 'A nonlethal murine cutaneous model of invasive aspergillosis'. Together they form a unique fingerprint.

Cite this