A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system

Robert G. Collum; Peter E. Fisher; Milton Datta; Scott Mellis; Carol Thiele; Kay Huebner; Carlo M. Croce; Mark A. Israel; Thomas Theil; Tarik Morory; Ronald Depinho; Frederick W. Alt

doi:10.1093/nar/20.18.4919

A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system

Robert G. Collum, Peter E. Fisher, Milton Datta, Scott Mellis, Carol Thiele, Kay Huebner, Carlo M. Croce, Mark A. Israel, Thomas Theil, Tarik Morory, Ronald Depinho, Frederick W. Alt

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

We report the isolation of a novel human POU domain encoding gene named RDC-1. The POU domain of the RDC encoded protein Is highly related to the POU domain potentially encoded by the rat brain-3 sequence and to that of the Drosophila1-POU protein; outside of the POU region, RDC-1 is unrelated to any previously characterized protein. The RDC-1 gene is expressed almost exclusively in normal tissues and transformed cells of neural origin. In the developing mouse and human fetus, RDC-1 is expressed in a spatially and temporally restricted pattern that suggests a critical role in the differentiation of neuronal tissues In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepfthellomas and Ewing's sarcomas but not neuroblastomas.Based on its unique structural characteristics and expression pattern, we discuss potential functions for the RDC-1 protein.

Original language	English (US)
Pages (from-to)	4919-4925
Number of pages	7
Journal	Nucleic acids research
Volume	20
Issue number	18
DOIs	https://doi.org/10.1093/nar/20.18.4919
State	Published - Sep 25 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system",

abstract = "We report the isolation of a novel human POU domain encoding gene named RDC-1. The POU domain of the RDC encoded protein Is highly related to the POU domain potentially encoded by the rat brain-3 sequence and to that of the Drosophila1-POU protein; outside of the POU region, RDC-1 is unrelated to any previously characterized protein. The RDC-1 gene is expressed almost exclusively in normal tissues and transformed cells of neural origin. In the developing mouse and human fetus, RDC-1 is expressed in a spatially and temporally restricted pattern that suggests a critical role in the differentiation of neuronal tissues In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepfthellomas and Ewing's sarcomas but not neuroblastomas.Based on its unique structural characteristics and expression pattern, we discuss potential functions for the RDC-1 protein.",

author = "Collum, {Robert G.} and Fisher, {Peter E.} and Milton Datta and Scott Mellis and Carol Thiele and Kay Huebner and Croce, {Carlo M.} and Israel, {Mark A.} and Thomas Theil and Tarik Morory and Ronald Depinho and Alt, {Frederick W.}",

note = "Funding Information: The Howard Hughes Medical Institute and the Departments of Biochemistry and Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY,1Molecular Genetics Section, Pediatric Branch, National Institutes of Health, Bethesda, MD,2Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, PA, department of Neurological Surgery and Pediatrics, Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA, USA, 4lnstitut fur Molekularbiologie und Tumorforschung, Philipps Universitat, Marburg, Germany and 5Departnnent of Microbiology, Albert Einstein University, Bronx, NY, USA",

year = "1992",

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doi = "10.1093/nar/20.18.4919",

language = "English (US)",

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T1 - A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system

AU - Collum, Robert G.

AU - Fisher, Peter E.

AU - Datta, Milton

AU - Mellis, Scott

AU - Thiele, Carol

AU - Huebner, Kay

AU - Croce, Carlo M.

AU - Israel, Mark A.

AU - Theil, Thomas

AU - Morory, Tarik

AU - Depinho, Ronald

AU - Alt, Frederick W.

N1 - Funding Information: The Howard Hughes Medical Institute and the Departments of Biochemistry and Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY,1Molecular Genetics Section, Pediatric Branch, National Institutes of Health, Bethesda, MD,2Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, PA, department of Neurological Surgery and Pediatrics, Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA, USA, 4lnstitut fur Molekularbiologie und Tumorforschung, Philipps Universitat, Marburg, Germany and 5Departnnent of Microbiology, Albert Einstein University, Bronx, NY, USA

PY - 1992/9/25

Y1 - 1992/9/25

N2 - We report the isolation of a novel human POU domain encoding gene named RDC-1. The POU domain of the RDC encoded protein Is highly related to the POU domain potentially encoded by the rat brain-3 sequence and to that of the Drosophila1-POU protein; outside of the POU region, RDC-1 is unrelated to any previously characterized protein. The RDC-1 gene is expressed almost exclusively in normal tissues and transformed cells of neural origin. In the developing mouse and human fetus, RDC-1 is expressed in a spatially and temporally restricted pattern that suggests a critical role in the differentiation of neuronal tissues In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepfthellomas and Ewing's sarcomas but not neuroblastomas.Based on its unique structural characteristics and expression pattern, we discuss potential functions for the RDC-1 protein.

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A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system

Abstract

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