TY - JOUR
T1 - A phase II study alternating alpha‐2a‐interferon and gamma‐interferon therapy in patients with chronic myelogenous leukemia
AU - Talpaz, M.
AU - Kurzrock, R.
AU - Kantarjian, H.
AU - Rothberg, J.
AU - Saks, S.
AU - Evans, L.
AU - Gutterman, J. U.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1991/11/15
Y1 - 1991/11/15
N2 - Patients with Philadelphia chromosome‐positive chronic myelogenous leukemia (CML) were treated with a combination of alpha‐interferon and gamma‐interferon. Recombinant alpha‐2a‐interferon (Roferon‐A, Hoffmann‐LaRoche, Inc., Nutley, NJ) and recombinant gamma‐interferon (Genentech, Inc., South San Francisco, CA) were administered on alternating weeks each at doses ranging from 2 to 10 MU/m2 given intramuscularly. Of the 27 patients, 11 (41%) achieved complete hematologic remission (CHR) and 3 (11%) achieved partial hematologic remission (PHR). Responses were seen among 9 of 22 (41%) patients treated during the chronic phase of the disease and in 2 of 5 (40%) patients treated during the accelerated phase/second chronic phase. Cytogenetic responses were seen in six patients, including one complete response and five minor responses. Toxicities included flu‐like symptoms, which appeared to be more severe with gamma‐interferon than with alpha‐interferon, hypertriglyceridemia, and thrombocytopenia. In this limited study, an improved outcome was not observed for the combination regimen compared with alpha‐interferon alone. Cancer 68:2125–2130.
AB - Patients with Philadelphia chromosome‐positive chronic myelogenous leukemia (CML) were treated with a combination of alpha‐interferon and gamma‐interferon. Recombinant alpha‐2a‐interferon (Roferon‐A, Hoffmann‐LaRoche, Inc., Nutley, NJ) and recombinant gamma‐interferon (Genentech, Inc., South San Francisco, CA) were administered on alternating weeks each at doses ranging from 2 to 10 MU/m2 given intramuscularly. Of the 27 patients, 11 (41%) achieved complete hematologic remission (CHR) and 3 (11%) achieved partial hematologic remission (PHR). Responses were seen among 9 of 22 (41%) patients treated during the chronic phase of the disease and in 2 of 5 (40%) patients treated during the accelerated phase/second chronic phase. Cytogenetic responses were seen in six patients, including one complete response and five minor responses. Toxicities included flu‐like symptoms, which appeared to be more severe with gamma‐interferon than with alpha‐interferon, hypertriglyceridemia, and thrombocytopenia. In this limited study, an improved outcome was not observed for the combination regimen compared with alpha‐interferon alone. Cancer 68:2125–2130.
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U2 - 10.1002/1097-0142(19911115)68:10<2125::AID-CNCR2820681006>3.0.CO;2-Q
DO - 10.1002/1097-0142(19911115)68:10<2125::AID-CNCR2820681006>3.0.CO;2-Q
M3 - Article
C2 - 1913450
AN - SCOPUS:0025992507
SN - 0008-543X
VL - 68
SP - 2125
EP - 2130
JO - Cancer
JF - Cancer
IS - 10
ER -