A Phase I/II Study of Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Squamous Cell Cancer of the Head and Neck

Stephen G. Chun; Randall Hughes; Baran D. Sumer; Larry L. Myers; John M. Truelson; Saad A. Khan; Tsung Wei Ma; Yang Xie; John S. Yordy; Susan Cooley; Jean Wu; Hak Choy; Lucien A. Nedzi

doi:10.1080/07357907.2016.1213275

A Phase I/II Study of Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Squamous Cell Cancer of the Head and Neck

Stephen G. Chun, Randall Hughes, Baran D. Sumer, Larry L. Myers, John M. Truelson, Saad A. Khan, Tsung Wei Ma, Yang Xie, John S. Yordy, Susan Cooley, Jean Wu, Hak Choy, Lucien A. Nedzi

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Nab-paclitaxel might impact efficacy of radiation for head and neck (H&N) cancer. Nab-paclitaxel, cisplatin, cetuximab, and radiation were evaluated in patients with locally advanced head and neck cancer in this phase I/II trial. Median follow-up was 24 months for 34 patients. The maximum tolerated dose of nab-paclitaxel was 20 mg/m² with 20 mg/m² cisplatin and 250 mg/m² cetuximab. The 2-year progression-free survival (PFS) was 60% (95% confidence interval (CI) 0.42, 0.78), local control 71% (95% CI 0.55, 0.87), and overall survival 68% (95% CI 0.50, 0.86). This is the first study evaluating these agents with radiation in humans, with similar 2-year PFS as historic control.

Original language	English (US)
Pages (from-to)	23-31
Number of pages	9
Journal	Cancer Investigation
Volume	35
Issue number	1
DOIs	https://doi.org/10.1080/07357907.2016.1213275
State	Published - Jan 2 2017

Keywords

Abraxane
cisplatin
erbitux
head and neck cancer
radiation therapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1080/07357907.2016.1213275

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Chun, S. G., Hughes, R., Sumer, B. D., Myers, L. L., Truelson, J. M., Khan, S. A., Ma, T. W., Xie, Y., Yordy, J. S., Cooley, S., Wu, J., Choy, H., & Nedzi, L. A. (2017). A Phase I/II Study of Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Squamous Cell Cancer of the Head and Neck. Cancer Investigation, 35(1), 23-31. https://doi.org/10.1080/07357907.2016.1213275

Chun, SG, Hughes, R, Sumer, BD, Myers, LL, Truelson, JM, Khan, SA, Ma, TW, Xie, Y, Yordy, JS, Cooley, S, Wu, J, Choy, H & Nedzi, LA 2017, 'A Phase I/II Study of Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Squamous Cell Cancer of the Head and Neck', Cancer Investigation, vol. 35, no. 1, pp. 23-31. https://doi.org/10.1080/07357907.2016.1213275

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abstract = "Nab-paclitaxel might impact efficacy of radiation for head and neck (H&N) cancer. Nab-paclitaxel, cisplatin, cetuximab, and radiation were evaluated in patients with locally advanced head and neck cancer in this phase I/II trial. Median follow-up was 24 months for 34 patients. The maximum tolerated dose of nab-paclitaxel was 20 mg/m2 with 20 mg/m2 cisplatin and 250 mg/m2 cetuximab. The 2-year progression-free survival (PFS) was 60% (95% confidence interval (CI) 0.42, 0.78), local control 71% (95% CI 0.55, 0.87), and overall survival 68% (95% CI 0.50, 0.86). This is the first study evaluating these agents with radiation in humans, with similar 2-year PFS as historic control.",

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AU - Khan, Saad A.

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AU - Yordy, John S.

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AB - Nab-paclitaxel might impact efficacy of radiation for head and neck (H&N) cancer. Nab-paclitaxel, cisplatin, cetuximab, and radiation were evaluated in patients with locally advanced head and neck cancer in this phase I/II trial. Median follow-up was 24 months for 34 patients. The maximum tolerated dose of nab-paclitaxel was 20 mg/m2 with 20 mg/m2 cisplatin and 250 mg/m2 cetuximab. The 2-year progression-free survival (PFS) was 60% (95% confidence interval (CI) 0.42, 0.78), local control 71% (95% CI 0.55, 0.87), and overall survival 68% (95% CI 0.50, 0.86). This is the first study evaluating these agents with radiation in humans, with similar 2-year PFS as historic control.

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A Phase I/II Study of Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Squamous Cell Cancer of the Head and Neck

Abstract

Keywords

ASJC Scopus subject areas

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