Abstract
In vitro γ-radiation-induced chromatid breaks per cell (b/c) in lymphocytes may be associated with risk of papillary thyroid cancer (PTC). This pilot case-control study involved 106 patients with thyroid disease (57 with PTC and 49 with benign thyroid disease) and 105 cancer-free matched controls. Multivariate logistic regression analyses identified that an elevated γ-radiation-induced b/c value was a risk factor for PTC (adjusted odds ratio = 4.54; 95% CI, 2.07-9.95), and a dose-response relationship was evident when the b/c values were categorized into tertiles. High levels of chromatid breaks induced by γ-radiation may constitute an independent risk factor for PTC, but further study is needed.
Original language | English (US) |
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Pages (from-to) | 94-99 |
Number of pages | 6 |
Journal | Thyroid |
Volume | 15 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2005 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology