TY - JOUR
T1 - A pilot quality-of-life instrument for acne rosacea
AU - Nicholson, Kimberly
AU - Abramova, Liana
AU - Chren, Mary Margaret
AU - Yeung, Jensen
AU - Chon, Susan Y.
AU - Chen, Suephy C.
N1 - Funding Information:
Supported in part from an American Skin Association (ASA) Health Services Research Grant, the ASA David Martin Carter Research Scholar Award, and an Emory Skin Disease Research Center Pilot and Feasibility grant (No. P30AR42687) from the National Institute on Arthritis and Musculoskeletal and Skin Disease (NIAMS), National Institutes of Health (NIH). Dr Chen is supported in part by a Mentored Patient Oriented Career Development Award (No. K23AR02185-01A1) from NIAMS, NIH.
PY - 2007/8
Y1 - 2007/8
N2 - Background: No rosacea-specific quality-of-life (QOL) instrument exists. Objective: We sought to develop a validated, reliable rosacea-specific instrument. Methods: From 6 in-depth interviews, we composed 21 rosacea-specific items. These items and Skindex-29 were administered in a validation cohort (n = 59). Internal consistency reliability and reproducibility were measured with Cronbach's coefficient α and intraclass correlation coefficient, respectively. Responsiveness was assessed comparing baseline with 4- to 6-month responses. Construct validity was assessed with principal axes factor analyses. Discriminant validity was examined with an additional 38 patients comparing differences in responsiveness between the rosacea-specific QOL instrument and Skindex. Results: Reliability was high (Cronbach's α: 0.82-0.97, intraclass correlation coefficient: 0.70-0.95). The rosacea-specific QOL instrument showed preliminary responsiveness for patients with improved disease (P ≤ .05). Principal axes factor analyses correlated to hypothesized scales (r = 0.57-0.82). Discriminant validity was illustrated with greater differences in responsiveness using the rosacea-specific QOL instrument (P = .008). Limitations: Potential selection bias and lack of generalizability was a limitation. Conclusions: The rosacea-specific QOL instrument, RosaQoL, appears to be a reliable and valid QOL instrument and shows preliminary responsiveness for patients with improving rosacea.
AB - Background: No rosacea-specific quality-of-life (QOL) instrument exists. Objective: We sought to develop a validated, reliable rosacea-specific instrument. Methods: From 6 in-depth interviews, we composed 21 rosacea-specific items. These items and Skindex-29 were administered in a validation cohort (n = 59). Internal consistency reliability and reproducibility were measured with Cronbach's coefficient α and intraclass correlation coefficient, respectively. Responsiveness was assessed comparing baseline with 4- to 6-month responses. Construct validity was assessed with principal axes factor analyses. Discriminant validity was examined with an additional 38 patients comparing differences in responsiveness between the rosacea-specific QOL instrument and Skindex. Results: Reliability was high (Cronbach's α: 0.82-0.97, intraclass correlation coefficient: 0.70-0.95). The rosacea-specific QOL instrument showed preliminary responsiveness for patients with improved disease (P ≤ .05). Principal axes factor analyses correlated to hypothesized scales (r = 0.57-0.82). Discriminant validity was illustrated with greater differences in responsiveness using the rosacea-specific QOL instrument (P = .008). Limitations: Potential selection bias and lack of generalizability was a limitation. Conclusions: The rosacea-specific QOL instrument, RosaQoL, appears to be a reliable and valid QOL instrument and shows preliminary responsiveness for patients with improving rosacea.
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U2 - 10.1016/j.jaad.2007.01.048
DO - 10.1016/j.jaad.2007.01.048
M3 - Article
C2 - 17445948
AN - SCOPUS:34447302591
SN - 0190-9622
VL - 57
SP - 213
EP - 221
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -