Abstract
In a carefully monitored pilot study, the in vivo biologic effects of filgrastim were investigated in eight patients with relapsed/refractory acute myelogenous leukemia. Within each patient, filgrastim was administered as a single agent prior to any chemotherapy in escalating doses of 0.12-6.0 μg/kg/day as a continuous intravenous infusion. The dose was increased every 14 days until an ANC of ≥2500/mm3 had been achieved or there was evidence of proliferation of the leukemia. In patients who demonstrated growth of the leukemic clone, cytosine arabinoside was initiated at 200 mg/m2/day for 5 days. Throughout the course of therapy, the effects of filgrastim on maturation and proliferation were assessed by in vitro studies of bone marrow aspirates. Three patients demonstrated a sustained increase in ANC; one achieved a partial remission and remained on therapy for 31 weeks. Two of the three responding patients had hypocellular marrows at the time of initiating filgrastim and demonstrated a low but normal pattern of growth in CFU-GM assay early in the treatment course. This suggested that these two characteristics may define an environment in which filgrastim can induce a growth advantage for the normal residual hematopoietic elements. In this study of selected patients, filgrastim appeared safe.
Original language | English (US) |
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Pages (from-to) | 1799-1804 |
Number of pages | 6 |
Journal | Leukemia |
Volume | 9 |
Issue number | 11 |
State | Published - Nov 1995 |
Keywords
- Filgrastim
- G-CSF
- Leukemia
- Maturation
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research