A pivoting algorithm for metabolic networks in the presence of thermodynamic constraints

R. Nigam; S. Liang

doi:10.1109/CSB.2005.6

A pivoting algorithm for metabolic networks in the presence of thermodynamic constraints

R. Nigam, S. Liang

Bioinformatics & Computational Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

A linear programming algorithm is presented to constructively compute thermodynamically feasible fluxes and change in chemical potentials of reactions for a metabolic network. It is based on physical laws of mass conservation and the second law of thermodynamics that all chemical reactions should satisfy. As a demonstration, the algorithm has been applied to the core metabolic pathway of E. coli.

Original language	English (US)
Title of host publication	Proceedings - 2005 IEEE Computational SystemsBioinformatics Conference, CSB 2005
Pages	259-267
Number of pages	9
DOIs	https://doi.org/10.1109/CSB.2005.6
State	Published - 2005
Event	2005 IEEE Computational Systems Bioinformatics Conference, CSB 2005 - Stanford, CA, United States Duration: Aug 8 2005 → Aug 11 2005

Publication series

Name	Proceedings - 2005 IEEE Computational Systems Bioinformatics Conference, CSB 2005
Volume	2005

Other

Other	2005 IEEE Computational Systems Bioinformatics Conference, CSB 2005
Country/Territory	United States
City	Stanford, CA
Period	8/8/05 → 8/11/05

ASJC Scopus subject areas

General Engineering
General Medicine

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10.1109/CSB.2005.6

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A pivoting algorithm for metabolic networks in the presence of thermodynamic constraints. / Nigam, R.; Liang, S.
Proceedings - 2005 IEEE Computational SystemsBioinformatics Conference, CSB 2005. 2005. p. 259-267 1498027 (Proceedings - 2005 IEEE Computational Systems Bioinformatics Conference, CSB 2005; Vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Nigam, R & Liang, S 2005, A pivoting algorithm for metabolic networks in the presence of thermodynamic constraints. in Proceedings - 2005 IEEE Computational SystemsBioinformatics Conference, CSB 2005., 1498027, Proceedings - 2005 IEEE Computational Systems Bioinformatics Conference, CSB 2005, vol. 2005, pp. 259-267, 2005 IEEE Computational Systems Bioinformatics Conference, CSB 2005, Stanford, CA, United States, 8/8/05. https://doi.org/10.1109/CSB.2005.6

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AB - A linear programming algorithm is presented to constructively compute thermodynamically feasible fluxes and change in chemical potentials of reactions for a metabolic network. It is based on physical laws of mass conservation and the second law of thermodynamics that all chemical reactions should satisfy. As a demonstration, the algorithm has been applied to the core metabolic pathway of E. coli.

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BT - Proceedings - 2005 IEEE Computational SystemsBioinformatics Conference, CSB 2005

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Y2 - 8 August 2005 through 11 August 2005

ER -

A pivoting algorithm for metabolic networks in the presence of thermodynamic constraints

Abstract

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