TY - JOUR
T1 - A population-based case-control study on serum lipids in relation to biliary tract cancer and cholelithiasis in Shanghai, China
AU - Shao, Changxia
AU - Gao, Yutang
AU - Cheng, Jiarong
AU - Deng, Jie
AU - Wang, Bingsheng
AU - Shen, Mingchang
AU - Han, Tianquan
AU - Zhang, Baihe
AU - Rashid, Asif
AU - Hsing, Ann W.
PY - 2006
Y1 - 2006
N2 - Objective: To investigate the levels of plasma lipids in patients with bile-tract cancer and cholelithiasis and to study the relationship between them. Methods: A population-based case-control study was conducted in urban Shanghai. Six indices of serum lipids were assayed in 462 new cases of biliary tract cancers, 982 patients with cholelithiasis and 808 healthy subjects. Non-parametric statistical method (Kruskal-Wallis rank sum test) was used to analyze and compare the level of serum lipids among patients with biliary tract cancer, gallstones and the normal controls. Results: Among male patients with gallstones, the concentration of triglycerides (TG) in biliary tract cancer patients was higher than that in cholelithiasis patients and the normal controls. The levels of HDL were statistically different among biliary tract cancer, cholelithiasis patients and the normal controls. Moreover, the levels of HDL were lower among the cases of all three sites of biliary tract cancers and gallstone disease patients than those in the normal controls. Among male subjects without gallstones, the concentrations of TG and ApoB in the group with biliary tract cancers were higher compared to those in the control group, while the concentrations of TC, HDL, LDL and ApoA were lower than those in the controls. Among female subjects with cholelithiasis, the levels of HDL and ApoA were statistically different among patients of biliary tract cancers, gallstone disease patients and normal controls. For female subjects without gallstones, the mean concentrations of HDL and ApoA among biliary tract cancers patients were significantly lower than those in normal controls. Conclusion: For both genders, lipoprotein metabolism abnormalities with hypertriglyceridemia and low serum levels of HDL were observed among biliary tract cancers.
AB - Objective: To investigate the levels of plasma lipids in patients with bile-tract cancer and cholelithiasis and to study the relationship between them. Methods: A population-based case-control study was conducted in urban Shanghai. Six indices of serum lipids were assayed in 462 new cases of biliary tract cancers, 982 patients with cholelithiasis and 808 healthy subjects. Non-parametric statistical method (Kruskal-Wallis rank sum test) was used to analyze and compare the level of serum lipids among patients with biliary tract cancer, gallstones and the normal controls. Results: Among male patients with gallstones, the concentration of triglycerides (TG) in biliary tract cancer patients was higher than that in cholelithiasis patients and the normal controls. The levels of HDL were statistically different among biliary tract cancer, cholelithiasis patients and the normal controls. Moreover, the levels of HDL were lower among the cases of all three sites of biliary tract cancers and gallstone disease patients than those in the normal controls. Among male subjects without gallstones, the concentrations of TG and ApoB in the group with biliary tract cancers were higher compared to those in the control group, while the concentrations of TC, HDL, LDL and ApoA were lower than those in the controls. Among female subjects with cholelithiasis, the levels of HDL and ApoA were statistically different among patients of biliary tract cancers, gallstone disease patients and normal controls. For female subjects without gallstones, the mean concentrations of HDL and ApoA among biliary tract cancers patients were significantly lower than those in normal controls. Conclusion: For both genders, lipoprotein metabolism abnormalities with hypertriglyceridemia and low serum levels of HDL were observed among biliary tract cancers.
KW - Biliary tract cancers
KW - Cholelithiasis
KW - Serum-lipids
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M3 - Article
AN - SCOPUS:84865051147
SN - 1000-8179
VL - 33
SP - 814-817+824
JO - Chinese Journal of Clinical Oncology
JF - Chinese Journal of Clinical Oncology
IS - 14
ER -