A possible autocrine role for interleukin-6 in two lymphoma cell lines

C. Yee; A. Biondi; X. H. Wang; N. N. Iscove; J. De Sousa; L. A. Aarden; G. G. Wong; S. C. Clark; H. A. Messner; M. D. Minden

doi:10.1182/blood.v74.2.798.798

A possible autocrine role for interleukin-6 in two lymphoma cell lines

C. Yee, A. Biondi, X. H. Wang, N. N. Iscove, J. De Sousa, L. A. Aarden, G. G. Wong, S. C. Clark, H. A. Messner, M. D. Minden

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secretion of IL-6 by two lymphoma cell lines, OCI-LY3 and OCI-LY12. Addition of recombinant IL-6 stimulated their growth, whereas addition of polyclonal anti-recombinant IL-6 (anti-rIL-6) had a marked inhibitory effect on proliferation. These results suggest an autocrine role for IL-6 in the growth of these lymphoma cells in culture.

Original language	English (US)
Pages (from-to)	798-804
Number of pages	7
Journal	Blood
Volume	74
Issue number	2
DOIs	https://doi.org/10.1182/blood.v74.2.798.798
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood.v74.2.798.798

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title = "A possible autocrine role for interleukin-6 in two lymphoma cell lines",

abstract = "Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secretion of IL-6 by two lymphoma cell lines, OCI-LY3 and OCI-LY12. Addition of recombinant IL-6 stimulated their growth, whereas addition of polyclonal anti-recombinant IL-6 (anti-rIL-6) had a marked inhibitory effect on proliferation. These results suggest an autocrine role for IL-6 in the growth of these lymphoma cells in culture.",

author = "C. Yee and A. Biondi and Wang, {X. H.} and Iscove, {N. N.} and {De Sousa}, J. and Aarden, {L. A.} and Wong, {G. G.} and Clark, {S. C.} and Messner, {H. A.} and Minden, {M. D.}",

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doi = "10.1182/blood.v74.2.798.798",

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T1 - A possible autocrine role for interleukin-6 in two lymphoma cell lines

AU - Yee, C.

AU - Biondi, A.

AU - Wang, X. H.

AU - Iscove, N. N.

AU - De Sousa, J.

AU - Aarden, L. A.

AU - Wong, G. G.

AU - Clark, S. C.

AU - Messner, H. A.

AU - Minden, M. D.

PY - 1989

Y1 - 1989

N2 - Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secretion of IL-6 by two lymphoma cell lines, OCI-LY3 and OCI-LY12. Addition of recombinant IL-6 stimulated their growth, whereas addition of polyclonal anti-recombinant IL-6 (anti-rIL-6) had a marked inhibitory effect on proliferation. These results suggest an autocrine role for IL-6 in the growth of these lymphoma cells in culture.

AB - Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secretion of IL-6 by two lymphoma cell lines, OCI-LY3 and OCI-LY12. Addition of recombinant IL-6 stimulated their growth, whereas addition of polyclonal anti-recombinant IL-6 (anti-rIL-6) had a marked inhibitory effect on proliferation. These results suggest an autocrine role for IL-6 in the growth of these lymphoma cells in culture.

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A possible autocrine role for interleukin-6 in two lymphoma cell lines

Abstract

ASJC Scopus subject areas

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