TY - JOUR
T1 - A prospective evaluation of staging and target volume definition of lymph nodes by 18FDG PET/CT in patients with squamous cell carcinoma of thoracic esophagus
AU - Yu, Wen
AU - Fu, Xiao Long
AU - Zhang, Ying Jian
AU - Xiang, Jia Qing
AU - Shen, Lei
AU - Chang, Joe Y.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Purpose: To determine an optimal standardized uptake value (SUV) threshold for detecting lymph node (LN) metastases in esophageal cancer using 18F-Fluorodeoxyglucose positron emission tomography/computer tomography ( 18FDG PET/CT) and to define the resulting nodal target volume, using histopathology as a "gold standard." Methods: Sixteen patients with esophageal squamous cell carcinoma who underwent radical esophagectomy and three-field LN dissection after 18FDG PET/CT and CT scans were enrolled into this study. Locations of LN groups were recorded according to a uniform LN map. Diagnostic performance of different SUV thresholds was assessed by receiver operating characteristic analysis. The optimal cutoff SUV was determined by plotting the false-negative rate (FNR) and false-positive rate (FPR), the sum of both error rates (FNR+FPR), and accuracy against a hypothetical SUV threshold. For each patient, nodal gross tumor volumes (GTVNs) were generated with CT alone (GTVNCT), PET/CT (GTVNPET), and pathologic data (GTVNpath). GTVNCT or GTVNPET was compared with GTVNpath by means of a conformity index (CI), which is the intersection of the two GTVNs divided by the sum of them minus the intersection, e.g., CI CT&path = GTVN CT&path/(GTVN CT+ GTVN path - GTVN CT&path). Results: LN metastases occurred in 21 LN groups among the 144 specimens taken from the 16 patients. The area under the receiver operating characteristic curve was 0.9017 ± 0.0410. The plot of error rates showed a minimum of FNR+FPR for an SUV of 2.36, at which the sensitivity, specificity, and accuracy were 76.19%, 95.93%, and 93.06%, respectively, whereas those of CT were 33.33%, 94.31%, and 85.42% (p values: 0.0117, 0.7539, and 0.0266). Mean GTVN CT, GTVN PET, and GTVN path were 1.52 ± 2.38, 2.82 ± 4.51, and 2.68 ± 4.16cm 3, respectively. Mean CI CT&path and CI PET&path were 0.31 and 0.65 (p value = 0.0352). Conclusions: Diagnostic superiority of PET/CT at an SUV threshold of 2.36 over CT has potential value in nodal target volume definition, but whether this can contribute to better treatment outcomes needs prospective analyses of recurrences in a larger cohort of patients.
AB - Purpose: To determine an optimal standardized uptake value (SUV) threshold for detecting lymph node (LN) metastases in esophageal cancer using 18F-Fluorodeoxyglucose positron emission tomography/computer tomography ( 18FDG PET/CT) and to define the resulting nodal target volume, using histopathology as a "gold standard." Methods: Sixteen patients with esophageal squamous cell carcinoma who underwent radical esophagectomy and three-field LN dissection after 18FDG PET/CT and CT scans were enrolled into this study. Locations of LN groups were recorded according to a uniform LN map. Diagnostic performance of different SUV thresholds was assessed by receiver operating characteristic analysis. The optimal cutoff SUV was determined by plotting the false-negative rate (FNR) and false-positive rate (FPR), the sum of both error rates (FNR+FPR), and accuracy against a hypothetical SUV threshold. For each patient, nodal gross tumor volumes (GTVNs) were generated with CT alone (GTVNCT), PET/CT (GTVNPET), and pathologic data (GTVNpath). GTVNCT or GTVNPET was compared with GTVNpath by means of a conformity index (CI), which is the intersection of the two GTVNs divided by the sum of them minus the intersection, e.g., CI CT&path = GTVN CT&path/(GTVN CT+ GTVN path - GTVN CT&path). Results: LN metastases occurred in 21 LN groups among the 144 specimens taken from the 16 patients. The area under the receiver operating characteristic curve was 0.9017 ± 0.0410. The plot of error rates showed a minimum of FNR+FPR for an SUV of 2.36, at which the sensitivity, specificity, and accuracy were 76.19%, 95.93%, and 93.06%, respectively, whereas those of CT were 33.33%, 94.31%, and 85.42% (p values: 0.0117, 0.7539, and 0.0266). Mean GTVN CT, GTVN PET, and GTVN path were 1.52 ± 2.38, 2.82 ± 4.51, and 2.68 ± 4.16cm 3, respectively. Mean CI CT&path and CI PET&path were 0.31 and 0.65 (p value = 0.0352). Conclusions: Diagnostic superiority of PET/CT at an SUV threshold of 2.36 over CT has potential value in nodal target volume definition, but whether this can contribute to better treatment outcomes needs prospective analyses of recurrences in a larger cohort of patients.
KW - Esophageal carcinoma
KW - Fluorodeoxyglucose (FDG)
KW - Positron emission tomography/computer tomography (PET/CT)
KW - Standardized uptake value (SUV)
KW - Target volume delineation
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U2 - 10.1016/j.ijrobp.2010.10.065
DO - 10.1016/j.ijrobp.2010.10.065
M3 - Article
C2 - 21470788
AN - SCOPUS:81855175299
SN - 0360-3016
VL - 81
SP - e759-e765
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 5
ER -