TY - JOUR
T1 - A prospective study of leukocyte telomere length and risk of renal cell carcinoma
AU - Hofmann, Jonathan N.
AU - Lan, Qing
AU - Cawthon, Richard
AU - Hosgood, H. Dean
AU - Shuch, Brian
AU - Moore, Lee E.
AU - Rothman, Nathaniel
AU - Chow, Wong Ho
AU - Purdue, Mark P.
PY - 2013/5
Y1 - 2013/5
N2 - Background: It has been hypothesized that genomic instability related to telomere dysfunction may contribute to carcinogenesis. There is some evidence from case-control studies suggesting that short leukocyte telomere length may be associated with an increased risk of renal cell carcinoma (RCC); however, this association has not been investigated prospectively. Methods: We conducted a nested case-control study (209 cases, 410 controls) of RCC risk in relation to prediagnostic leukocyte telomere length in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. ORs and 95% confidence intervals (CI) were estimated using conditional logistic regression. Results: Leukocyte telomere length was not significantly associated with future risk ofRCC(highest quartile vs. lowest: OR, 0.8; 95% CI, 0.5-1.5; Ptrend = 0.6). Analyses stratified by sex, age, and time from blood collection to RCC diagnosis were similarly null. Conclusions: The results of this study, to our knowledge the first prospective investigation of its kind, do not support an association between prediagnostic leukocyte telomere length and risk of RCC. Impact: In contrast to some earlier reports, our findings add to the evidence that leukocyte telomere length is not a biomarker of risk related to the etiology of RCC. Cancer Epidemiol Biomarkers Prev; 22(5); 997-1000.
AB - Background: It has been hypothesized that genomic instability related to telomere dysfunction may contribute to carcinogenesis. There is some evidence from case-control studies suggesting that short leukocyte telomere length may be associated with an increased risk of renal cell carcinoma (RCC); however, this association has not been investigated prospectively. Methods: We conducted a nested case-control study (209 cases, 410 controls) of RCC risk in relation to prediagnostic leukocyte telomere length in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. ORs and 95% confidence intervals (CI) were estimated using conditional logistic regression. Results: Leukocyte telomere length was not significantly associated with future risk ofRCC(highest quartile vs. lowest: OR, 0.8; 95% CI, 0.5-1.5; Ptrend = 0.6). Analyses stratified by sex, age, and time from blood collection to RCC diagnosis were similarly null. Conclusions: The results of this study, to our knowledge the first prospective investigation of its kind, do not support an association between prediagnostic leukocyte telomere length and risk of RCC. Impact: In contrast to some earlier reports, our findings add to the evidence that leukocyte telomere length is not a biomarker of risk related to the etiology of RCC. Cancer Epidemiol Biomarkers Prev; 22(5); 997-1000.
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U2 - 10.1158/1055-9965.EPI-13-0142
DO - 10.1158/1055-9965.EPI-13-0142
M3 - Review article
C2 - 23513041
AN - SCOPUS:84877995215
SN - 1055-9965
VL - 22
SP - 997
EP - 1000
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -