A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas

Toshiyuki Kamoto; Hayase Shisa; Abujiang Pataer; Ling Min Lu; Osamu Yoshida; Yoshihiro Yamada; Hiroshi Hiai

doi:10.1111/j.1349-7006.1996.tb00236.x

A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas

Toshiyuki Kamoto, Hayase Shisa, Abujiang Pataer, Ling Min Lu, Osamu Yoshida, Yoshihiro Yamada, Hiroshi Hiai

Thoracic & Cardiovascular Surgery

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effects of two host genes on retrovirus-induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T-lymphoma-bearing F2 mice, 45 had the AKR-derived dominant allele at Tlsm-1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh-derived allele at a major histocompatibility complex (MHC)-linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh-derived recessive gene was named lla (lymphoma latency acceleration).

Original language	English (US)
Pages (from-to)	401-404
Number of pages	4
Journal	Japanese Journal of Cancer Research
Volume	87
Issue number	4
DOIs	https://doi.org/10.1111/j.1349-7006.1996.tb00236.x
State	Published - Apr 1996

Keywords

Latency
MHC
Mouse lymphoma
Quantitative trait locus
SL/Kh mouse

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1111/j.1349-7006.1996.tb00236.x

Cite this

@article{4040c23023be477a9fccabac33db1889,

title = "A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas",

abstract = "The effects of two host genes on retrovirus-induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T-lymphoma-bearing F2 mice, 45 had the AKR-derived dominant allele at Tlsm-1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh-derived allele at a major histocompatibility complex (MHC)-linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh-derived recessive gene was named lla (lymphoma latency acceleration).",

keywords = "Latency, MHC, Mouse lymphoma, Quantitative trait locus, SL/Kh mouse",

author = "Toshiyuki Kamoto and Hayase Shisa and Abujiang Pataer and Lu, {Ling Min} and Osamu Yoshida and Yoshihiro Yamada and Hiroshi Hiai",

year = "1996",

month = apr,

doi = "10.1111/j.1349-7006.1996.tb00236.x",

language = "English (US)",

volume = "87",

pages = "401--404",

journal = "Japanese Journal of Cancer Research",

issn = "0910-5050",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas

AU - Kamoto, Toshiyuki

AU - Shisa, Hayase

AU - Pataer, Abujiang

AU - Lu, Ling Min

AU - Yoshida, Osamu

AU - Yamada, Yoshihiro

AU - Hiai, Hiroshi

PY - 1996/4

Y1 - 1996/4

N2 - The effects of two host genes on retrovirus-induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T-lymphoma-bearing F2 mice, 45 had the AKR-derived dominant allele at Tlsm-1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh-derived allele at a major histocompatibility complex (MHC)-linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh-derived recessive gene was named lla (lymphoma latency acceleration).

AB - The effects of two host genes on retrovirus-induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T-lymphoma-bearing F2 mice, 45 had the AKR-derived dominant allele at Tlsm-1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh-derived allele at a major histocompatibility complex (MHC)-linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh-derived recessive gene was named lla (lymphoma latency acceleration).

KW - Latency

KW - MHC

KW - Mouse lymphoma

KW - Quantitative trait locus

KW - SL/Kh mouse

UR - http://www.scopus.com/inward/record.url?scp=0030044016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030044016&partnerID=8YFLogxK

U2 - 10.1111/j.1349-7006.1996.tb00236.x

DO - 10.1111/j.1349-7006.1996.tb00236.x

M3 - Article

C2 - 8641972

AN - SCOPUS:0030044016

SN - 0910-5050

VL - 87

SP - 401

EP - 404

JO - Japanese Journal of Cancer Research

JF - Japanese Journal of Cancer Research

IS - 4

ER -

A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this