A rapid assay of suramin in plasma

W. P. Tong; H. I. Scher; D. P. Petrylak; A. Dnistrian; T. Curley; J. Vasquez

doi:10.1080/01483919008049030

A rapid assay of suramin in plasma

W. P. Tong, H. I. Scher, D. P. Petrylak, A. Dnistrian, T. Curley, J. Vasquez

Cancer Systems Imaging

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22 Scopus citations

Abstract

The polysulfonated napthylurea suramin is currently undergoing extensive clinical trials. A narrow therapeutic window requires frequent dose adjustment to minimize toxicity. A simple, rapid and reproducible assay was developed for measuring suramin levels in plasma. Plasma samples are injected directly onto the column and eluted isocratically with acetonitrile and an ion pairing reagent. Retention time is approximately two minutes, recovery greater than 95% throughout the range of 50–300 ug/ml, with sensitivities to concentrations of 5 ug. A small sample size (0.5 ul) gave similar results allowing assays of finger-stick samples. Equal accuracy was.

Original language	English (US)
Pages (from-to)	2269-2284
Number of pages	16
Journal	Journal of Liquid Chromatography
Volume	13
Issue number	11
DOIs	https://doi.org/10.1080/01483919008049030
State	Published - 1990

ASJC Scopus subject areas

Molecular Medicine

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10.1080/01483919008049030

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title = "A rapid assay of suramin in plasma",

abstract = "The polysulfonated napthylurea suramin is currently undergoing extensive clinical trials. A narrow therapeutic window requires frequent dose adjustment to minimize toxicity. A simple, rapid and reproducible assay was developed for measuring suramin levels in plasma. Plasma samples are injected directly onto the column and eluted isocratically with acetonitrile and an ion pairing reagent. Retention time is approximately two minutes, recovery greater than 95% throughout the range of 50–300 ug/ml, with sensitivities to concentrations of 5 ug. A small sample size (0.5 ul) gave similar results allowing assays of finger-stick samples. Equal accuracy was.",

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AU - Tong, W. P.

AU - Scher, H. I.

AU - Petrylak, D. P.

AU - Dnistrian, A.

AU - Curley, T.

AU - Vasquez, J.

PY - 1990

Y1 - 1990

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AB - The polysulfonated napthylurea suramin is currently undergoing extensive clinical trials. A narrow therapeutic window requires frequent dose adjustment to minimize toxicity. A simple, rapid and reproducible assay was developed for measuring suramin levels in plasma. Plasma samples are injected directly onto the column and eluted isocratically with acetonitrile and an ion pairing reagent. Retention time is approximately two minutes, recovery greater than 95% throughout the range of 50–300 ug/ml, with sensitivities to concentrations of 5 ug. A small sample size (0.5 ul) gave similar results allowing assays of finger-stick samples. Equal accuracy was.

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A rapid assay of suramin in plasma

Abstract

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