A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters

Amy L. Eastwood; Angela P. Blum; Niki M. Zacharias; Dennis A. Dougherty

doi:10.1021/jo901368g

A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters

Amy L. Eastwood, Angela P. Blum, Niki M. Zacharias, Dennis A. Dougherty

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

(Chemical Equation Presented) A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins.

Original language	English (US)
Pages (from-to)	9241-9244
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	74
Issue number	23
DOIs	https://doi.org/10.1021/jo901368g
State	Published - Dec 4 2009
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo901368g

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title = "A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters",

abstract = "(Chemical Equation Presented) A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins.",

author = "Eastwood, {Amy L.} and Blum, {Angela P.} and Zacharias, {Niki M.} and Dougherty, {Dennis A.}",

year = "2009",

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doi = "10.1021/jo901368g",

language = "English (US)",

volume = "74",

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journal = "Journal of Organic Chemistry",

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T1 - A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters

AU - Eastwood, Amy L.

AU - Blum, Angela P.

AU - Zacharias, Niki M.

AU - Dougherty, Dennis A.

PY - 2009/12/4

Y1 - 2009/12/4

N2 - (Chemical Equation Presented) A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins.

AB - (Chemical Equation Presented) A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins.

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DO - 10.1021/jo901368g

M3 - Article

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AN - SCOPUS:72249100349

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 23

ER -

A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters

Abstract

ASJC Scopus subject areas

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