A specific α-fetoprotein gene binding protein in α-fetoprotein producing rat hepatomas

Zhi Wang; Gilbert J. Cote; Jen Fu Chiu

doi:10.1016/0006-291X(87)90637-1

A specific α-fetoprotein gene binding protein in α-fetoprotein producing rat hepatomas

Zhi Wang, Gilbert J. Cote, Jen Fu Chiu

Endocrine Neoplasia & HD

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A specific α-fetoprotein (AFP) gene binding nuclear protein (Mol. Wt. 149,000) was determined in Morris hepatoma 7777 cells by the protein blotting technique. This protein is not present in normal adult rat liver and non-AFP producing Morris hepatoma 5123tc. Neoplasia induced in rats fed the hepatocarcinogen 3′-methyl-4-dimethylaminoazobenzine enhanced AFP gene activity and re-expressed specific AFP gene binding nuclear protein. The precise role of this protein in AFP gene regulation remains to be determined.

Original language	English (US)
Pages (from-to)	110-115
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	143
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(87)90637-1
State	Published - Feb 27 1987

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "A specific α-fetoprotein gene binding protein in α-fetoprotein producing rat hepatomas",

abstract = "A specific α-fetoprotein (AFP) gene binding nuclear protein (Mol. Wt. 149,000) was determined in Morris hepatoma 7777 cells by the protein blotting technique. This protein is not present in normal adult rat liver and non-AFP producing Morris hepatoma 5123tc. Neoplasia induced in rats fed the hepatocarcinogen 3′-methyl-4-dimethylaminoazobenzine enhanced AFP gene activity and re-expressed specific AFP gene binding nuclear protein. The precise role of this protein in AFP gene regulation remains to be determined.",

author = "Zhi Wang and Cote, {Gilbert J.} and Chiu, {Jen Fu}",

note = "Funding Information: This investigation was supported in parts by USPHS Grants CA25098 and CH42969 awarded by NCI. G. J. Cote was a trainee of Cancer Biology Training Grant T32-09286. We thank Mrs. Jeanette Mann for her assistance in the preparation of this manuscript.",

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AU - Wang, Zhi

AU - Cote, Gilbert J.

AU - Chiu, Jen Fu

N1 - Funding Information: This investigation was supported in parts by USPHS Grants CA25098 and CH42969 awarded by NCI. G. J. Cote was a trainee of Cancer Biology Training Grant T32-09286. We thank Mrs. Jeanette Mann for her assistance in the preparation of this manuscript.

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N2 - A specific α-fetoprotein (AFP) gene binding nuclear protein (Mol. Wt. 149,000) was determined in Morris hepatoma 7777 cells by the protein blotting technique. This protein is not present in normal adult rat liver and non-AFP producing Morris hepatoma 5123tc. Neoplasia induced in rats fed the hepatocarcinogen 3′-methyl-4-dimethylaminoazobenzine enhanced AFP gene activity and re-expressed specific AFP gene binding nuclear protein. The precise role of this protein in AFP gene regulation remains to be determined.

AB - A specific α-fetoprotein (AFP) gene binding nuclear protein (Mol. Wt. 149,000) was determined in Morris hepatoma 7777 cells by the protein blotting technique. This protein is not present in normal adult rat liver and non-AFP producing Morris hepatoma 5123tc. Neoplasia induced in rats fed the hepatocarcinogen 3′-methyl-4-dimethylaminoazobenzine enhanced AFP gene activity and re-expressed specific AFP gene binding nuclear protein. The precise role of this protein in AFP gene regulation remains to be determined.

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A specific α-fetoprotein gene binding protein in α-fetoprotein producing rat hepatomas

Abstract

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