Abstract
Autophagy is an attractive therapeutic target in cancer. Successful autophagy-focused clinical intervention will require a detailed understanding of when and where autophagy is important during tumorigenesis. In this issue of Cancer Research, Khayati and colleagues use state-of-the-art genetically engineered mouse models to demonstrate that transient systemic inhibition of autophagy can irreversibly impair the growth of established lung tumors with a good tolerability in normal tissues, suggesting a therapeutic strategy for cancer treatment.
Original language | English (US) |
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Pages (from-to) | 4322-4324 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 82 |
Issue number | 23 |
DOIs | |
State | Published - Dec 1 2022 |
ASJC Scopus subject areas
- Oncology
- Cancer Research