TY - JOUR
T1 - A track repeating algorithm for intensity modulated carbon ion therapy
AU - Wang, Qianxia
AU - Adair, Antony
AU - Deng, Yu
AU - Chen, Hongliang
AU - Moyers, Michael
AU - Lin, James
AU - Yepes, Pablo
N1 - Publisher Copyright:
© 2019 Institute of Physics and Engineering in Medicine.
PY - 2019/5/2
Y1 - 2019/5/2
N2 - The fast dose calculator (FDC), a track repeating Monte Carlo (MC) algorithm was initially developed for proton therapy. The validation for proton therapy has been demonstrated in a previous work. In this work we presented the extension of FDC to the calculation of dose distributions for ions, particularly for carbon. Moreover the code algorithm is validated by comparing 3D dose distributions and dose volume histograms (DVH) calculated by FDC with Geant4. A total of 19 patients were employed, including three patients of prostate, five of brain, three of head and neck, four of lung and four of spine. We used a gamma-index technique to analyze dose distributions and we performed a dosimetric analysis for DVHs, a more direct and informative quantity for planning system assessment. The gamma-index passing rates of all patients discussed in this paper are above 90% with the criterion 1%/1 mm, above 98% with the criterion 2%/2 mm and over 99.9% with the criterion 3%/3 mm. The root mean square (RMS) of percent difference of dosimetric indices D 02, D 05, D 50, D 95 and D 98 are 0.75%, 0.70%, 0.79%, 0.83% and 0.76%. All the differences are within clinically accepted norms.
AB - The fast dose calculator (FDC), a track repeating Monte Carlo (MC) algorithm was initially developed for proton therapy. The validation for proton therapy has been demonstrated in a previous work. In this work we presented the extension of FDC to the calculation of dose distributions for ions, particularly for carbon. Moreover the code algorithm is validated by comparing 3D dose distributions and dose volume histograms (DVH) calculated by FDC with Geant4. A total of 19 patients were employed, including three patients of prostate, five of brain, three of head and neck, four of lung and four of spine. We used a gamma-index technique to analyze dose distributions and we performed a dosimetric analysis for DVHs, a more direct and informative quantity for planning system assessment. The gamma-index passing rates of all patients discussed in this paper are above 90% with the criterion 1%/1 mm, above 98% with the criterion 2%/2 mm and over 99.9% with the criterion 3%/3 mm. The root mean square (RMS) of percent difference of dosimetric indices D 02, D 05, D 50, D 95 and D 98 are 0.75%, 0.70%, 0.79%, 0.83% and 0.76%. All the differences are within clinically accepted norms.
KW - 3D-dose
KW - DVH
KW - gamma-index
KW - Geant4
KW - Monte Carlo
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U2 - 10.1088/1361-6560/ab10d0
DO - 10.1088/1361-6560/ab10d0
M3 - Article
C2 - 30884469
AN - SCOPUS:85065555324
SN - 0031-9155
VL - 64
JO - Physics in medicine and biology
JF - Physics in medicine and biology
IS - 9
M1 - 095026
ER -