A unique description of stage IV extranodal marginal zone lymphoma (EMZL) in an adolescent associated with gamma heavy chain disease

Nupur Mittal; Bing Zhu; Sujata Gaitonde; Yang Lu; Mary Lou Schmidt

doi:10.1002/pbc.25419

A unique description of stage IV extranodal marginal zone lymphoma (EMZL) in an adolescent associated with gamma heavy chain disease

Nupur Mittal, Bing Zhu, Sujata Gaitonde, Yang Lu, Mary Lou Schmidt

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Extranodal Marginal zone lymphoma (EMZL) is a rare, usually localized disease in children. Advanced stage EMZL in adults is considered incurable, with prolonged remissions after chemotherapy. Gamma heavy chain disease (γHCD) is a rare disease of adults associated with lympho-proliferative processes with no comparable reports in children. A case of stage-IV EMZL with γHCD in an adolescent is discussed including treatment with Bendamustine plus Rituximab. The patient remains disease free 18 months from diagnosis. This case highlights necessity for careful diagnostic work-up to identify indolent lymphomas in children which may respond to less toxic chemotherapy than used for common pediatric lymphomas. Pediatr Blood Cancer 2015;62:905-908.

Original language	English (US)
Pages (from-to)	905-908
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	62
Issue number	5
DOIs	https://doi.org/10.1002/pbc.25419
State	Published - May 1 2015
Externally published	Yes

Keywords

Bendamustine-rituximab
Extranodal marginal zone lymphoma
Gamma heavy chain disease
Pediatric NHL

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.25419

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title = "A unique description of stage IV extranodal marginal zone lymphoma (EMZL) in an adolescent associated with gamma heavy chain disease",

abstract = "Extranodal Marginal zone lymphoma (EMZL) is a rare, usually localized disease in children. Advanced stage EMZL in adults is considered incurable, with prolonged remissions after chemotherapy. Gamma heavy chain disease (γHCD) is a rare disease of adults associated with lympho-proliferative processes with no comparable reports in children. A case of stage-IV EMZL with γHCD in an adolescent is discussed including treatment with Bendamustine plus Rituximab. The patient remains disease free 18 months from diagnosis. This case highlights necessity for careful diagnostic work-up to identify indolent lymphomas in children which may respond to less toxic chemotherapy than used for common pediatric lymphomas. Pediatr Blood Cancer 2015;62:905-908.",

keywords = "Bendamustine-rituximab, Extranodal marginal zone lymphoma, Gamma heavy chain disease, Pediatric NHL",

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AU - Zhu, Bing

AU - Gaitonde, Sujata

AU - Lu, Yang

AU - Schmidt, Mary Lou

PY - 2015/5/1

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AB - Extranodal Marginal zone lymphoma (EMZL) is a rare, usually localized disease in children. Advanced stage EMZL in adults is considered incurable, with prolonged remissions after chemotherapy. Gamma heavy chain disease (γHCD) is a rare disease of adults associated with lympho-proliferative processes with no comparable reports in children. A case of stage-IV EMZL with γHCD in an adolescent is discussed including treatment with Bendamustine plus Rituximab. The patient remains disease free 18 months from diagnosis. This case highlights necessity for careful diagnostic work-up to identify indolent lymphomas in children which may respond to less toxic chemotherapy than used for common pediatric lymphomas. Pediatr Blood Cancer 2015;62:905-908.

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A unique description of stage IV extranodal marginal zone lymphoma (EMZL) in an adolescent associated with gamma heavy chain disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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