TY - JOUR
T1 - A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck
T2 - A case-control analysis
AU - Shen, Hongbing
AU - Sturgis, Erich M.
AU - Dahlstrom, Kristina R.
AU - Zheng, Yuxin
AU - Spitz, Margaret R.
AU - Wei, Qingyi
PY - 2002/6/20
Y1 - 2002/6/20
N2 - Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we tested the hypothesis that a C to T variant (Thr241Met) of DNA repair gene X-ray repair cross-complementing group 3 (XRCC3) is associated with risk of developing squamous cell carcinoma of the head and neck (SCCHN). We genotyped for this variant in 367 non-Hispanic white patients newly diagnosed with SCCHN and 354 frequency-matched cancer-free controls. Compared with the XRCC3 18067CC and 18607CT genotypes, the variant XRCC3 18067TT genotype was associated with a non- statistically significantly increased risk of SCCHN (adjusted odds ratio [ORadj], 1.36; 95% confidence interval [Cl], 0.89-2.08), but this risk was significantly increased among female subjects (ORadj 2.23, 95% Cl, 1.00-4.98) and current smokers (ORadj, 2.26; 95% Cl, 1.02-4.99). These findings suggest that the variant XRCC3 18067TT genotype may not play a major role in the etiology of SCCHN but may contribute to a subset of SCCHN. Larger studies are needed to verify these findings.
AB - Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we tested the hypothesis that a C to T variant (Thr241Met) of DNA repair gene X-ray repair cross-complementing group 3 (XRCC3) is associated with risk of developing squamous cell carcinoma of the head and neck (SCCHN). We genotyped for this variant in 367 non-Hispanic white patients newly diagnosed with SCCHN and 354 frequency-matched cancer-free controls. Compared with the XRCC3 18067CC and 18607CT genotypes, the variant XRCC3 18067TT genotype was associated with a non- statistically significantly increased risk of SCCHN (adjusted odds ratio [ORadj], 1.36; 95% confidence interval [Cl], 0.89-2.08), but this risk was significantly increased among female subjects (ORadj 2.23, 95% Cl, 1.00-4.98) and current smokers (ORadj, 2.26; 95% Cl, 1.02-4.99). These findings suggest that the variant XRCC3 18067TT genotype may not play a major role in the etiology of SCCHN but may contribute to a subset of SCCHN. Larger studies are needed to verify these findings.
KW - DNA repair
KW - Genetic polymorphism
KW - Head and neck cancer
KW - Molecular epidemiology
KW - XRCC3
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U2 - 10.1002/ijc.10413
DO - 10.1002/ijc.10413
M3 - Article
C2 - 12115490
AN - SCOPUS:0037142183
SN - 0020-7136
VL - 99
SP - 869
EP - 872
JO - International journal of cancer
JF - International journal of cancer
IS - 6
ER -