Aaptamine derivatives from the indonesian sponge Aaptos suberitoides

Cong Dat Pham; Rudolf Hartmann; Werner E.G. Müller; Nicole De Voogd; Daowan Lai; Peter Proksch

doi:10.1021/np300794b

Aaptamine derivatives from the indonesian sponge Aaptos suberitoides

Cong Dat Pham, Rudolf Hartmann, Werner E.G. Müller, Nicole De Voogd, Daowan Lai, Peter Proksch

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC₅₀ values ranging from 0.9 to 8.3 μM.

Original language	English (US)
Pages (from-to)	103-106
Number of pages	4
Journal	Journal of Natural Products
Volume	76
Issue number	1
DOIs	https://doi.org/10.1021/np300794b
State	Published - Jan 25 2013
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np300794b

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AU - Lai, Daowan

AU - Proksch, Peter

PY - 2013/1/25

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AB - Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC50 values ranging from 0.9 to 8.3 μM.

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Aaptamine derivatives from the indonesian sponge Aaptos suberitoides

Abstract

ASJC Scopus subject areas

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