TY - JOUR
T1 - Abdominal insufflation does not cause hematogenous spread of colon cancer
AU - Hofstetter, Wayne
AU - Ortega, Adrian
AU - Chiang, Mimi
AU - Brown, Bill
AU - Paik, Peter
AU - Youn, Peter
AU - Beart, Robert W.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000/2
Y1 - 2000/2
N2 - Background and Purpose: Previous investigators have suggested that port- site recurrences are possibly a result of abdominal insufflation, forcing viable cancer cells into the circulation to metastasize and thrive in areas of trauma. Using a syngeneic animal cancer model, we tested the hypothesis that pneumoperitoneum increases the incidence of wound metastasis by a blood- borne mechanism. Methods: Male BD IX rats (N = 150) were injected intraperitoneally with 2 x 105 viable syngeneic 1,2-dimethylhydralazine- induced colon cancer cells (DHD-K12). Animals were divided into three groups: A (abdominal insufflation with 3-cm incision on the back into muscle remote from the peritoneum); B (3-cm back incision alone); and C (control group with 3-cm midline abdominal incision). Three weeks after surgery, the animals were euthanized and autopsied. Results: In the two groups with back wounds, the incidence of cancer growth at the incision was zero, as demonstrated grossly and by histologic sample (A: 0/47, B: 0/43). In contrast, the autopsied control group had a 42% incidence of metastasis to the wound (25/59). There seemed to be no difference in the distribution of intra-abdominal disease between those rats that underwent insufflation and those that did not. Conclusion: It is unlikely that pneumoperitoneum promotes hematogenous wound implantation of free intraperitoneal cancer cells.
AB - Background and Purpose: Previous investigators have suggested that port- site recurrences are possibly a result of abdominal insufflation, forcing viable cancer cells into the circulation to metastasize and thrive in areas of trauma. Using a syngeneic animal cancer model, we tested the hypothesis that pneumoperitoneum increases the incidence of wound metastasis by a blood- borne mechanism. Methods: Male BD IX rats (N = 150) were injected intraperitoneally with 2 x 105 viable syngeneic 1,2-dimethylhydralazine- induced colon cancer cells (DHD-K12). Animals were divided into three groups: A (abdominal insufflation with 3-cm incision on the back into muscle remote from the peritoneum); B (3-cm back incision alone); and C (control group with 3-cm midline abdominal incision). Three weeks after surgery, the animals were euthanized and autopsied. Results: In the two groups with back wounds, the incidence of cancer growth at the incision was zero, as demonstrated grossly and by histologic sample (A: 0/47, B: 0/43). In contrast, the autopsied control group had a 42% incidence of metastasis to the wound (25/59). There seemed to be no difference in the distribution of intra-abdominal disease between those rats that underwent insufflation and those that did not. Conclusion: It is unlikely that pneumoperitoneum promotes hematogenous wound implantation of free intraperitoneal cancer cells.
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U2 - 10.1089/lap.2000.10.1
DO - 10.1089/lap.2000.10.1
M3 - Article
C2 - 10706295
AN - SCOPUS:0034104466
SN - 1092-6429
VL - 10
SP - 1
EP - 4
JO - Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A
JF - Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A
IS - 1
ER -